A comparison of danazol and conservative surgery for the treatment of infertility due to mild or moderate endometriosis

David S. Guzick, John A. Rock
In: Fertility and Sterility · 1983 · vol. 40(5) , pp. 580–584 · doi:10.1016/s0015-0282(16)47412-1 · W3021532146
article OA: closed CC0 ⤵ 34 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study compared danazol treatment to conservative surgery for infertility caused by mild or moderate endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Although both medical and surgical therapy have been widely used in the treatment of infertility due to endometriosis, there is little information on the comparative success of these treatment modalities. In a group of 313 infertile women who presented to The Johns Hopkins Hospital with mild or moderate endometriosis in whom there had been no previous therapy, the results of danazol (91 patients) and conservative surgery (133 patients) were compared. It was found that the cumulative pregnancy curves of the two groups virtually coincided. There was no significant difference in the estimated proportion of patients who were "cured," i.e., who would ultimately conceive if followed for a long enough period (68.3% for surgery versus 74.0% for danazol), nor in the monthly rate of pregnancy among those cured (5.7% versus 4.0%), respectively.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (34)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK