Role of low dose danazol therapy for endometriosis related infertility and its comparison with laparoscopic fulguration in low resources

Urvashi Verma; Shivani Singh; Mukesh Chandra; Richa Singh; Mukul Chandra; Aruna Goel

doi:10.5455/2320-1770.ijrcog20140313

Role of low dose danazol therapy for endometriosis related infertility and its comparison with laparoscopic fulguration in low resources

Urvashi Verma, Shivani Singh, Mukesh Chandra, Richa Singh, Mukul Chandra, Aruna Goel

In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2014 · pp. 67–69 · doi:10.5455/2320-1770.ijrcog20140313 · W2122332584

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study compared laparoscopic fulguration and low-dose danazol therapy for endometriosis-related infertility, finding comparable conception rates and symptom relief in both groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This cross-sectional study (n=100, ages 20–39) in a single obstetrics/gynecology department compared low-dose danazol therapy with laparoscopic fulguration for endometriosis-related infertility in symptomatic women assessed via history, labs, transvaginal ultrasound, and laparoscopy. On laparoscopy, 52% had red lesions and 22% had normal findings, and ultrasound showed that most patients (70%) had normal scans aside from smaller subsets with cysts. Pelvic pain and dysmenorrhea were relieved in 64% with danazol, and conception occurred in 52%, while laparoscopic fulguration relieved symptoms in 69% and resulted in 60% conception, with the authors concluding results were comparable while noting therapy choice depended on factors including age, infertility duration, findings, surgeon experience, and resource availability. This paper is centrally about endometriosis—specifically comparing low-dose danazol versus laparoscopic fulguration for endometriosis-related infertility in a low-resource setting.

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Abstract

Background: The objective was to study the role of laparoscopic fulguration and danazol therapy for endometriosis in case of infertility followed by comparison of both therapies. Methods: The present cross–sectional study was conducted in the department of obstetrics and gynecology SN Medical College Agra. Over the period from December 2010 to November 2013. Symptomatic women (n=50) of age group 20-39 yrs coming to gynecology OPD were selected for study group. The study group was subjected to detailed history, physical examination laboratory test, ultrasound examination, and laparoscopy. Then 50 patients were allotted for laparoscopic fulguration and 50 for danazol treatment. Results: Out of 100 on transvaginal sonography, 10%of patient have cyst 2cm size, rest 70% have normal scan. On laparoscopy 52% of patient have red lesion, 16% have bluish black lesion, 20% have yellow brown lesion rest 22% have normal findings. On danazol therapy pelvic pain and dysmenorrhoea was relieved in 64% and 52% conceived .on laparoscopic fulguration symptom were relieved in 69% and 60% conceived. Conclusions: Based on this study it can be concluded that choice of therapy depend on age of patient, duration of infertility, physical findings, goal of surgery, experience of surgeon and most important the availability of resources. In this study result was comparable.