Towards gene therapy of endometriosis

Anastasia Shubina, Anton Kiselev, Anna Egorova, Баранов Владислав Сергеевич, Владислав Сергеевич Баранов
In: Journal of obstetrics and women's diseases · 2012 · vol. 61(3) , pp. 148–158 · doi:10.17816/jowd613148-158 · W2491224616
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review explores current and future gene therapy strategies for endometriosis, detailing anti-estrogenic, anti-angiogenic, and suicidal approaches along with siRNA/miRNA-mediated gene expression regulation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper discusses gene therapy concepts for endometriosis by outlining therapeutic nucleic-acid delivery approaches (viral versus non-viral vectors; antisense oligonucleotides, microRNAs, and small interfering RNAs) and the rationale for targeting genes involved in endometriosis pathogenesis. It reviews high-level mechanisms in endometriosis—including estrogen-dependent steroid metabolism changes, progesterone resistance, immune dysregulation with elevated inflammatory cytokines, angiogenesis driven by VEGF and related pathways, and identified genetic/epigenetic alterations such as differential DNA methylation and altered microRNA expression—and links these to candidate molecular targets for gene-engineering strategies. A major caveat is that the article is a theoretical/overview paper rather than presenting experimental data or clinical efficacy results, and it notes lingering uncertainty in endometriosis etiology and pathogenesis despite many studies. This paper is centrally about endometriosis — it specifically frames endometriosis mechanisms as targets for gene therapy and reviews candidate pathways and delivery strategies relevant to that approach.

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Abstract

Review of current state and future prospects of endometriosis gene therapy is presented. Main molecular pathogenetic mechanisms and possible ways of their correction by means of genetic constructs are described. Examples of anti-estrogenic, anti-angiogenic, suicidal gene therapy approaches are presented. Advantages of siRNA and microRNA mediated regulation of endometrial genes expression are discussed

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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