[Alteration of peritoneal lymphocyte transformation and its interleukin-2 release in patients with infertility and endometriosis]
Observational
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CC0
⤵ 6 in-corpus citations
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Endometriosis patients exhibited enhanced peritoneal lymphocyte transformation and increased interleukin-2 levels compared to controls, suggesting a role in infertility.
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Abstract
OBJECTIVE: To study the relationship between alteration of peritoneal lymphocyte transformation activity, its interleukin-2 (IL-2) release and infertility associated with endometriosis.
METHODS: Peritoneal fluid was collected from 15 infertile patients with endometriosis (endometriosis group) and 13 normal fertile women (control group). Lymphocyte transformation activity were determined in peritoneal fluid by morphometry. IL-2 contents were determined in peritoneal fluid and supernatants of cultured pelvic lymphocytes by biological method.
RESULTS: Lymphocyte transformation activity reinforced (P < 0.001) and IL-2 contents increased in peritoneal fluid and supernatant of cultured pelvic lymphocyte in the endometriosis group than those in the control group (P < 0.01, P < 0.001 respectively). There is significant positive correlation between lymphocyte transformation rate and IL-2 activity of cultured supernatant in endometriosis group (P < 0.001).
CONCLUSION: The increase of IL-2 content in the samples of endometriosis may play an important role in infertility with endometriosis.
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Cited by (6)
- The Multifactorial Pathogenesis of Endometriosis: A Narrative Review Integrating Hormonal, Immune, and Microbiome Aspects 2025
- The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility 2023
- The Role of the Immune System in the Development of Endometriosis 2022
- Endometrial Flushing Tumor Necrosis Factor Alpha and Interleukin 2 Levels in Women with Polycystic Ovary Syndrome, Leiomyoma and Endometrioma: Comparison with Healthy Controls 2019
- The estimation of IL-2 and IL-2 receptors in peritoneal fluid of infertile patients with endometriosis 2007
- Interleukin-2 receptor beta (IL-2R beta)-627*C homozygote but not IL-12R beta 1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis 2005
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- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T20:59:14.592962+00:00
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