Vitamin D and infertility

Samantha Simpson, Simpson S, Lubna Pal, Pal L
Current opinion in obstetrics & gynecology · 2023 · vol. 35(4) , pp. 300–305 · doi:10.1097/gco.0000000000000887 · PMID:37266579 · W4379093651
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Vitamin D deficiency may contribute to infertility and gynecological disorders, with supplementation potentially improving pregnancy rates, ovarian reserve, fibroid growth, endometriosis symptoms, and PCOS markers.

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Abstract

PURPOSE OF REVIEW: Vitamin D deficiency has been implicated as a contributing factor to a spectrum of reproductive health burden, including difficulty conceiving, pathogenesis of gynaecological disorders such as uterine fibroids and endometriosis, to metabolic and endocrine burden of polycystic ovarian syndrome (PCOS). RECENT FINDINGS: There have been recent publications showing that in infertile women who are supplemented with vitamin D, there are higher pregnancy rates; there are improved ovarian reserve parameters in women with diminished ovarian reserve; curtailed fibroid growth in those with uterine myomas; lessened dysmenorrhea in endometriosis patients; and improved menstrual regularity, lowered testosterone, AMH and insulin levels in women with PCOS. In infertile men, sperm parameters, especially motility, are positively correlated with vitamin D serum levels. SUMMARY: Vitamin D status appears to be relevant to reproductive physiology, and to physiological processes underlying common gynaecological disorders as well as for reproductive success.

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Condition tags

endometriosisdysmenorrheainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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References (58)

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