Applications of microarray in reproductive medicine

Chen HW, Huei-Wen Chen, Huei‐Wen Chen, Chii-Ruey Tzeng, Chii‐Ruey Tzeng, Tzeng CR
Chang Gung medical journal · 2006 · vol. 29(1) , pp. 15–24 · PMID:16642725 · W2411483452
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This review discusses how cDNA microarray technology, particularly when combined with LCM and aRNA amplification, is applied in reproductive medicine to study gene expression related to oocyte fertilization, embryo development, implantation, and infertility.

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Abstract

In the genomic era, cDNA microarray (DNA chip) technology has become a very important and powerful tool for high-throughput comprehensive analysis of gene expression, genotyping and re-sequencing applications in almost every field of biomedical research. Large-scale transcriptional profiling analyses using microarrays are frequently used to explore gene expression patterns in order to better understand the molecular mechanisms of physiology and pathogenesis: these are the basis for the development of new diagnostic and therapeutic strategies. Recently, this powerful technique has been used with laser capture microdissection (LCM) and linear aRNA amplification (in vitro transcription), and used in reproductive medical research. Recent studies of microarray-related techniques used to study oocyte fertilization, early embryo development, implantation and some infertility-related diseases (endometriosis and myoma) are discussed and summarized in this review.

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Condition tags

endometriosisinfertility

MeSH descriptors

Embryonic Development Embryonic Development Endometriosis Gene Expression Profiling Gene Expression Profiling Leiomyoma Oligonucleotide Array Sequence Analysis Placenta Uterine Neoplasms Animals Animals Endometriosis Endometriosis Female Female Humans Humans Leiomyoma Leiomyoma Oligonucleotide Array Sequence Analysis

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