Prostaglandins and their Synthesis Inhibitors in Primary Dysmenorrhoea

In: Practical Applications of Prostaglandins and their Synthesis Inhibitors · 1979 · pp. 217–235 · doi:10.1007/978-94-011-7843-3_11 · W43648349
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Primary dysmenorrhea pain, attributed to uterine hyper-contractility, can be managed by suppressing prostaglandin synthesis with prostaglandin synthetase inhibitors.

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Abstract

Primary dysmenorrhoea may be regarded as a syndrome that includes not only pain in the lower abdomen and back but also a variety of other symptoms. However, pain is the primary complaint, often attributed to uterine cramps, which makes the uterus a focus of attention. Amongst the various factors that may be responsible for this pain, uterine hyper-contractility has received particular attention. When it became evident that prostaglandins play a major role in the control of uterine contractility it was logical to try and suppress the synthesis of these substances with prostaglandin synthetase inhibitors (PGSI) and thereby prevent uterine cramps. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

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Prostaglandins, 13, 8I I Pickles, V. R., Hall. W. J., Best, F. A. and Smith, C. N. (1965). Prostaglandins in endometrium and menstrual fluid from normal and dysmenorrhoeic subjects. J. Obstet. Grnecol. Br. C mrbh, 72, 185 Pulkkinen, M. O. and Kaihola, H.-L. (1977). Mefenamic acid in dysmenorrhoea. Acio Obstet. Grnecol Scand, 56. 75 Shangold. M. M., Aksel, S., Schoenberg, D. W. and Hammond, C. B. (1976). Plasma prostaglandin F2, levels in dysmenorrhoeic women. Feet. Steril, 27, 1171 Editor information Editors and Affiliations Rights and permissions Copyright information © 1979 MTP Press Limited About this chapter Cite this chapter Wiqvist, N. (1979). Prostaglandins and their Synthesis Inhibitors in Primary Dysmenorrhoea. In: Karim, S.M.M. (eds) Practical Applications of Prostaglandins and their Synthesis Inhibitors. Advances in Prostaglandin Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7843-3_11 Download citation DOI: https://doi.org/10.1007/978-94-011-7843-3_11 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-011-7845-7 Online ISBN: 978-94-011-7843-3 eBook Packages: Springer Book Archive

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