Analysis of WNT4 polymorphism in Chinese Han women with endometriosis

Zhaohua Wu, Zhangying Wu, Ming Yuan, Yuan M, Yan Li, Li Y, Fangfang Fu, Fu F, Wenqinq Ma, Ma W, Li H, Haixia Li, Wenwen Wang, Wang W, Shixuan Wang, Wang S
Reproductive biomedicine online · 2015 · vol. 30(4) , pp. 415–420 · doi:10.1016/j.rbmo.2014.12.010 · PMID:25682310 · W2102082576
article OA: bronze CC0 ⤵ 13 in-corpus citations
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This study analyzed the WNT4 gene polymorphism in Chinese Han women to identify associations with endometriosis.

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Abstract

Endometriosis is a complex disease that is influenced by genetic and environmental factors. In endometriosis, WNT4 plays a likely role owing to its biological functions. In this study, the TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single nucleotide polymorphisms in WNT4 (rs7521902 [A/C], rs16826658 [G/T], rs7515106 [C/T] and rs2235529 [A/G]) in Chinese Han women. A total of 646 patients with endometriosis and 766 normal controls were recurited. Regression analyses revealed that rs2235529 was a risk locus for endometriosis (P = 1.80E-03, OR, 95% CI = 1.311, 1.129 to 1.522), particularly in patients with stage III and IV disease. No significant association was found between endometriosis and rs7521902 (A/C), rs16826658 (G/T), or rs7515106 (C/T). For each of the four single nucleotide polymorphisms, no association was found between patients with endometriosis-related infertility or primary infertility and the controls. The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Polymorphism, Single Nucleotide Wnt4 Protein Adult Alleles Asian People Asian People Case-Control Studies China Endometriosis Female Gene Frequency Genotype Humans Middle Aged Wnt4 Protein

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