Chronic demyelination interferes with normal spermatogenesis in cuprizone-intoxicant C57/BL 6 mice: An experimental study

Arezoo Dorikhani, Ameneh Omidi, Mansoureh Movahedin, Iman Halvaei
In: International Journal of Reproductive BioMedicine (IJRM) · 2024 · vol. 22(1) , pp. 43–54 · doi:10.18502/ijrm.v22i1.15241 · PMID:38544672 · W4392167879
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Chronic demyelination induced by cuprizone intoxication in mice disrupted the hypothalamic-pituitary-gonadal axis, leading to testicular damage and impaired spermatogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

The study investigated whether chronic demyelination, induced by cuprizone intoxication in C57BL/6 mice, disrupts normal spermatogenesis. Using an experimental mouse model of demyelination, the authors assessed reproductive outcomes related to testicular sperm development and reported that demyelination interfered with normal spermatogenic processes. The key finding was that chronic demyelination was associated with impaired spermatogenesis compared with normal controls. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background: Due to myelin and axonal insults in multiple sclerosis individuals, motor coordination problems and endocrine imbalance may develop. Objective: This study aims to evaluate the role of chronic demyelination on the hypothalamic-pituitary-gonadal axis in the mouse model of multiple sclerosis. Materials and Methods: 20 adult C57/BL6 male mice were divided into 2 groups (n = 10/each) as follows: the control group (CONT) received a regular diet for 17 wk; and the experimental group (cuprizone [CPZ]) was fed with 0.2% CPZ for 12 wk and, then CPZ was withdrawn for 5 wk. Serum testosterone, histopathology of the brain and testis, and sperm analysis were evaluated. Results: wk of the study. Conclusion: Chronic demyelination induced by CPZ intoxication, maybe through damage to the hypothalamus arcuate nucleus, leads to the hypothalamic-pituitary-gonadal axis disturbance and damage to the testis and spermatogenesis subsequently.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 18 February 2024 Authors Arezoo Dorikhani | Ameneh Omidi | Mansoureh Movahedin | Iman Halvaei The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v22i1.15241', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/15241', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://ijrm.ir/article-1-3210-en.html', 'tld': 'ijrm.ir', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '18 February 2024', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Chronic demyelination interferes with normal spermatogenesis in cuprizone-intoxicant C57/BL 6 mice: An experimental study', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v22i1.15241', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Arezoo Dorikhani | Ameneh Omidi | Mansoureh Movahedin | Iman Halvaei', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v22i1.15241 JSON XML

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