Relief of uterine bleeding by cyclic administration of dienogest for endometriosis

Toru Yanase, Yanase T, Ikunosuke Tsuneki, Tsuneki I, Tamura M, Masaki Tamura, Kurabayashi T, Takumi Kurabayashi
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(11) , pp. 804–807 · doi:10.3109/09513590.2014.943717 · PMID:25060125 · W2154273807
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Cyclic dienogest administration reduced uterine bleeding days and menstrual pain in endometriosis patients undergoing ovarian cyst enucleation.

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Abstract

OBJECTIVE: This study assessed the relief of uterine bleeding and clinical symptoms during cyclic administration of dienogest for the treatment of endometriosis. METHODS: In total, 25 patients undergoing ovarian cyst enucleation and given dienogest participated in this study. Dienogest 2 mg/day was administered for 3 weeks, and the drug was then withdrawn for 1 week (cyclic administration of dienogest). This 4-week cycle was repeated six times. Patients' records were prospectively analyzed for the number of days on which any uterine bleeding occurred, as well as menstrual pain before and after the start of dienogest administration were evaluated with a view to using the data obtained herein as the basis. RESULTS: During the period of cyclic administration of dienogest, uterine bleeding occurred on 5.8 to 7.7 days per 4-week period on an average through cycles. Of uterine bleeding episodes, menstruation-like uterine bleeding was present in about 80% of patients. The visual analog scale (VAS) value for menstrual pain significantly decreased from 3.8 before dienogest administration after surgery to 1.5 at the completion of cycle 1, VAS remained low thereafter. CONCLUSION: These results raise the possibility that cyclic administration of dienogest may relieve lessen uterine bleeding, a major adverse event and menstrual pain.

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Outcome instruments

VAS-pain

Condition tags

endometriosis

MeSH descriptors

Endometriosis Hormone Antagonists Nandrolone Ovarian Diseases Uterine Hemorrhage Adult Drug Administration Schedule Endometriosis Female Hormone Antagonists Hormone Antagonists Humans Nandrolone Nandrolone Nandrolone Ovarian Diseases Treatment Outcome Uterine Hemorrhage Young Adult

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References (16)

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