Suppression of macrophage activation by peritoneal fluid from patients with endometriosis

Takeshita S, S. Takeshita, Shigeki Takeshita, Kazuyoshi Dobashi, Dobashi K, K Dobashi, Abe S, S Abe, Shigeru Abe, S Tansho, Shigeru Tansho, Tansho S, H Yamaguchi, Hideyo Yamaguchi, Yamaguchi H, Okinaga S, Shoichi Okinaga, S Okinaga, Hiroyuki Mori, H Mori, Mori H
FEMS immunology and medical microbiology · 1998 · vol. 20(4) , pp. 243–248 · doi:10.1111/j.1574-695x.1998.tb01133.x · PMID:9626928 · W1972444677
Lab / animal OA: bronze CC0 ⤵ 1 in-corpus citation
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Peritoneal fluid from endometriosis patients suppressed the tumor necrosis factor production of mouse peritoneal macrophages, suggesting a mechanism for immune tolerance in endometriosis.

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Abstract

To investigate the effects of peritoneal fluid from patients with endometriosis on mouse peritoneal macrophages (Mphi), peritoneal fluid from endometriosis patients (n = 15) were added to a monolayer of C3H/HeJ mouse peritoneal Mphi. Tumor necrosis factor-producing activity was measured by the L929 assay activated with FK-23 (a preparation of heat-killed Enterococcus faecalis). Tumor necrosis factor-producing activity of C3H/HeJ mouse peritoneal Mphi incubated with peritoneal fluid was suppressed in 14 endometriosis patients. Interestingly, in nine endometriosis patients, tumor necrosis factor-producing activity was much lower than seen with mouse peritoneal Mphi incubated with corticosterone. Peritoneal fluid contains suppressive properties for the activation of peritoneal Mphi, which might allow the implantation of free endometrial cells or the metaplastic phenomena stimulated by retrograde menstruation.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Biological Factors Endometriosis Macrophage Activation Macrophages, Peritoneal Tumor Necrosis Factor-alpha Adult Adult Age Factors Age Factors Animals Animals Ascitic Fluid Ascitic Fluid Ascitic Fluid Biological Factors Biological Factors Biological Factors Cell Line Cell Line

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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