Endometriosis y carcinoma de celulas claras. Reporte de caso

This paper reports a clinical case of a 54-year-old woman with a history of cesarean section and prior hysterectomy, who developed a slowly enlarging abdominal wall mass; imaging initially showed a right ovarian solid tumor, and CT-guided biopsy of the abdominal lesion suggested clear cell adenocarcinoma with endometriosis as a differential. After surgical resection of the abdominal mass with bilateral adnexectomy and selective lymphadenectomy, deferred pathology demonstrated clear cell adenocarcinoma arising in abdominal wall endometriosis with iliac lymph node involvement, and a later recurrence was evaluated and treated with cisplatin plus doxorubicin for six cycles, followed by a continued clinical decline after further lymphadenopathy growth. The authors discuss that malignant transformation of endometriosis is rare and that diagnosis relies on Sampson/Scott criteria including contiguous benign endometriosis and absence of another primary tumor; they also note the lack of a standardized management approach due to only ~30 reported cases and heterogeneous treatment strategies. This paper is centrally about endometriosis — specifically a case of clear cell carcinoma arising from abdominal wall endometriosis following a cesarean scar and its discussed management and criteria for malignant transformation.

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