Percutaneous cryoablation of symptomatic uterine adenomyomas: Initial experience

Clément Marcelin, Jean-Luc Brun, J.-L. Brun, Julie Caprais, Isabelle Molina-Andreo, Isabelle Molina-Andréo, Eva Jambon, Y. Le Bras, Yann Le Bras, Claude Hocké, Nicolas Grenier, N. Grenier
Journal of gynecology obstetrics and human reproduction · 2024 · vol. 53(3) , pp. 102727 · doi:10.1016/j.jogoh.2024.102727 · PMID:38237806 · W4391036031
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reports on the initial experience using percutaneous cryoablation to treat symptomatic uterine adenomyomas.

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Abstract

OBJECTIVE: To assess the efficacy and safety of percutaneous image-guided cryoablation of adenomyomas MATERIAL AND METHODS: Five symptomatic women who wanted to preserve their uterus and fertility underwent a single session of percutaneous image-guided cryoablation of adenomyoma. Three to six 17-gauge cryoprobes were introduced percutaneously into the adenomyoma under ultrasound and laparoscopy guidance. Clinical efficacy was defined as the diminution of the Visual Analogue Scale of pain (VAS), the decrease in uterine bleeding and the improvement of quality of life assessed by the endometriosis health profile 5 (EHP-5) 12 months after treatment. Technical efficacy was defined by the reduction in volume of each treated adenomyoma on MRI. Complications were classified using the Clavien-Dindo classification system. Hysterosonography was performed at least 3 months after the procedure. RESULTS: Compared to the baseline, all symptom scores had decreased after 12 months: median VAS 8/10 (range, 5-10) to 4/10 (range, 0-7); median dyspareunia score 7/10 (range, 0-10) to 2/10 (range, 0-8); median bleeding score 335 (range, 102-920) to 76 (range, 0-88); median EHP-5 score 60/100 (range, 50-75) to 50/100 (range, 32-55). The median volume of adenomyosis decreased from 57 cm3 (range, 8-87) to 9 cm3 (range, 2-45) at 12 months. No postoperative complications occurred. Two patients had incomplete intrauterine adhesions that were easily removed hysteroscopically. CONCLUSION: Cryoablation may be a promising alternative treatment for symptomatic adenomyoma in women who want to preserve their uterus.

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Condition tags

endometriosis

MeSH descriptors

Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Adenomyoma Cryosurgery Cryosurgery Cryosurgery Cryosurgery Cryosurgery Cryosurgery Cryosurgery Cryosurgery Cryosurgery

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (3)

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