The acute-phase response in endometriosis of women

G.A.J. Dunselman, Dunselman GA, G A Dunselman, Bouckaert PX, P X Bouckaert, P. X. J. M. Bouckaert, J L Evers, J.L.H. Evers
Journal of reproduction and fertility · 1988 · vol. 83(2) , pp. 803–808 · doi:10.1530/jrf.0.0830803 · PMID:3137342 · W2083585244
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Endometriosis patients showed no difference in peritoneal fluid volume but had significantly higher peritoneal fluid:serum protein ratios than controls, suggesting exudation governed by molecular weight.

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Abstract

Peritoneal fluid volume was determined and concentrations of C-reactive protein, alpha 1-antitrypsin, acid-alpha 1-glycoprotein, alpha 2-macroglobulin, haptoglobin, complement factors C3 and C4, IgG, IgA and IgM were measured in the supernatant of the peritoneal fluid and in serum by means of a radial-immunodiffusion technique in 25 patients with and in 45 patients without endometriosis. Peritoneal fluid volume was not different between the two groups. The peritoneal fluid:serum ratios for the proteins determined showed a significant inverse correlation with their molecular weight in both groups, indicating that their presence in peritoneal fluid is governed by exudation according to their molecular weight, rather than by active production in, or selective release into, the peritoneal cavity. In control patients only, the ratios of most of the individual proteins studied were significantly higher in the luteal than in the follicular phase. We suggest that the high values of peritoneal fluid:serum ratios in endometriotic tissue and peritoneal macrophages. In the luteal phase, the cycle-dependent increase of protein exudation obscures this additional contribution. We conclude that endometriosis does not cause marked intra-abdominal inflammatory changes. If the presence of endometriosis lowers fecundity, the mechanism probably does not involve acute-phase protein synthesis.

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Condition tags

endometriosis

MeSH descriptors

Acute-Phase Reaction Endometriosis Inflammation Acute-Phase Reaction Acute-Phase Reaction Acute-Phase Reaction Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Blood Proteins Blood Proteins Blood Proteins Endometriosis Endometriosis Endometriosis Female Female Follicular Phase

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (17)

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