Expression profiles of tRNA-derived fragments and their potential roles in ovarian endometriosis

Licong Shen, Shen L, Xiaxia Hong, Hong X, Wenjun Zhou, Zhou W, Yi Zhang
Epigenomics · 2019 · vol. 12(3) , pp. 183–197 · doi:10.2217/epi-2019-0277 · PMID:31845823 · W2996291766
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This study investigated tRNA-derived fragment expression profiles and their potential roles in the pathogenesis and progression of ovarian endometriosis.

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Abstract

Aim: Transfer RNA-derived fragments have been reported to play a vital role in disease progression, but their role in the pathogenesis of endometriosis remains unknown. Materials & methods: Small RNA sequencing was conducted in three paired ovarian endometriomas and eutopic endometria. The data from 22 paired samples were validated by quantitative real-time polymerase chain reaction (qPCR) and bioinformatic analysis was performed to establish the roles of these fragments in endometriosis pathogenesis. Results: We identified 19 upregulated and five downregulated tRNA-derived fragments, of which tiRNA-5 was the most common. Gene Ontology and pathway analyses revealed that these molecules could have roles in the pathogenesis of endometriosis. Conclusion: tRNA-derived fragments are dysregulated and could be involved in the pathogenesis and progression of ovarian endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Profiling Gene Expression Profiling Ovary RNA, Transfer Transcriptome Transcriptome Disease Progression Disease Progression Disease Susceptibility Disease Susceptibility Endometriosis Endometriosis Endometriosis Endometriosis Female Female Gene Expression Regulation Gene Expression Regulation Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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