Recognizing and treating endometriosis

Blamble T, Tiffany Blamble, Dickerson L, Lisa Dickerson
JAAPA : official journal of the American Academy of Physician Assistants · 2021 · vol. 34(6) , pp. 14–19 · doi:10.1097/01.jaa.0000750940.47126.58 · PMID:34031308 · W3164277344
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

This review covers endometriosis epidemiology, pathophysiology, clinical presentation, and treatments, including the GnRH antagonist elagolix, for women with and without fertility desires.

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Abstract

ABSTRACT: Endometriosis, defined as endometrium-like tissue located outside the uterine cavity, is a chronic and frequently painful disease that affects about 10% of reproductive-aged women worldwide. The ectopic endometrial tissue, which is still hormonally responsive, generates a chronic inflammatory state resulting in an array of sometimes debilitating symptoms as well as subfertility. Despite its prevalence and significant effect on a woman's health and quality of life, receiving a diagnosis of endometriosis often takes years. This article reviews the epidemiology, pathophysiology, clinical presentation, and treatment options for managing endometriosis in women who do not desire pregnancy and in those who do, and includes information on the newest treatment option, the oral gonadotropin-releasing hormone (GnRH) antagonist elagolix.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Infertility Adult Endometrium Female Gonadotropin-Releasing Hormone Hormone Antagonists Humans Quality of Life

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (7)

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