Effects of aging on menstrual cycle hormones and endometrial maturation

Marcelo C. Batista, Tannia P. Cartledge, Ann W. Zellmer, Maria J. Merino, Constantine A. Axiotis, William J. Bremner, Lynnette K. Nieman
In: Fertility and Sterility · 1995 · vol. 64(3) , pp. 492–499 · doi:10.1016/s0015-0282(16)57782-6 · PMID:7641900 · W119767941
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This study investigated menstrual cycle hormones and endometrial maturation in women aged 20-30 and 40-50, finding increased FSH and reduced inhibin in older women, while endometrial maturation was similar between groups.

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Effects of aging on menstrual cycle hormones and endometrial maturation Date relationships.isAuthorOf Merino, Maria J. Nieman, Lynnette K. Zellmer, Ann W. Bremner, William J. Axiotis, Constantine Batista, Marcelo C. Cartledge, Tannia P. Journal Title Journal ISSN Volume Title Publisher Elsevier Abstract OBJECTIVE: To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging. DESIGN: Prospective controlled clinical study. SETTING: Normal human volunteers in an academic research institution. SUBJECTS: Women with regular menstrual cycles. INTERVENTIONS: Thirty-two women, aged 20 to 30 or 40 to 50 years, had daily blood drawing starting on cycle day 6 to 10 and continuing until 2 days after the onset of next menses. In addition, 60 women, aged 20 to 30 or 40 to 50 years, had a total of 93 endometrial biopsies performed on day 7 to 9 after the LH surge. MAIN OUTCOME MEASURES: Serum LH, FSH, E2, inhibin, P, and placental protein 14 (PP14) levels and histologic maturation of the endometrium. RESULTS: Serum FSH levels were increased whereas inhibin concentrations were reduced in the luteal-follicular transition of women > 40 years. No other hormonal changes were seen in this population, including P and PP14 secretion. Disruption of endometrial maturation occurred at a similar frequency in both age groups. CONCLUSIONS: Follicular recruitment, but not luteal function or endometrial maturation, is disturbed in cycling women > 40 years and may contribute to the decline in fertility with aging. Description Citation Fertil Steril. 1995 Sep;64(3):492-9

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