{"paper_id":"64aa4b38-ce79-47fd-bd06-e2bcaa575e3f","body_text":"Effects of aging on menstrual cycle hormones and endometrial maturation\nDate\nrelationships.isAuthorOf\nMerino, Maria J.\nNieman, Lynnette K.\nZellmer, Ann W.\nBremner, William J.\nAxiotis, Constantine\nBatista, Marcelo C.\nCartledge, Tannia P.\nJournal Title\nJournal ISSN\nVolume Title\nPublisher\nElsevier\nAbstract\nOBJECTIVE: To investigate changes in menstrual cycle hormones and\nendometrial maturation that may contribute to the decline in fertility\nwith aging. DESIGN: Prospective controlled clinical study. SETTING: Normal\nhuman volunteers in an academic research institution. SUBJECTS: Women with\nregular menstrual cycles. INTERVENTIONS: Thirty-two women, aged 20 to 30\nor 40 to 50 years, had daily blood drawing starting on cycle day 6 to 10\nand continuing until 2 days after the onset of next menses. In addition,\n60 women, aged 20 to 30 or 40 to 50 years, had a total of 93 endometrial\nbiopsies performed on day 7 to 9 after the LH surge. MAIN OUTCOME\nMEASURES: Serum LH, FSH, E2, inhibin, P, and placental protein 14 (PP14)\nlevels and histologic maturation of the endometrium. RESULTS: Serum FSH\nlevels were increased whereas inhibin concentrations were reduced in the\nluteal-follicular transition of women > 40 years. No other hormonal\nchanges were seen in this population, including P and PP14 secretion.\nDisruption of endometrial maturation occurred at a similar frequency in\nboth age groups. CONCLUSIONS: Follicular recruitment, but not luteal\nfunction or endometrial maturation, is disturbed in cycling women > 40\nyears and may contribute to the decline in fertility with aging.\nDescription\nCitation\nFertil Steril. 1995 Sep;64(3):492-9","source_license":"CC0","license_restricted":false}