William J. Bremner

ORCID: 0000-0002-9769-2554 · 2 papers in corpus

nonrandomized-trial 2009

Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics

Cancer chemotherapy and pharmacology ·doi:10.1007/s00280-009-1038-1

PURPOSE: GnRH analogs are useful for the treatment of prostate cancer, but require parenteral administration. The peptide GnRH antagonist acyline potently suppresses luteinizing hormone (LH) and testosterone in man; however, its clinical ut…

rct 2002

Twenty-one day administration of dienogest reversibly suppresses gonadotropins and testosterone in normal men

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.5.8514

Androgen-progestin combinations are promising male contraceptive regimens. Optimization of these regimens includes the development of new progestins with more favorable biological properties. In this context we tested the effects of the pro…