Management of endometrial hyperplasia
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⤵ 15 in-corpus citations
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This review summarizes the current management of endometrial hyperplasia, focusing on etiology, risk of cancer, diagnosis, and treatment options including progestagens and hysterectomy.
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Abstract
Endometrial hyperplasia is a commonly seen clinical entity. A great majority of patients present with abnormal uterine bleeding. Unopposed estrogen either from an endogenous or exogenous source is the most important etiologic factor. Etiologic evaluation and cause specific treatment is a must for these patients instead of direct biopsies and treatments. Clinical importance of this pathological entity is the underlying risk of carrying a concomitant genital cancer and the potential risk of progression to endometrial carcinoma during the follow-up. Despite to a great effort on research and a long history of the disease in the medical literature; we still do not have a practical and accurate system available to use during daily practice in order to differentiate the real precancerous lesions. Treatment of endometrial hyperplasia depends on the patient's age, fertility desire and the type of present hyperplasia. Progestagens are still the most commonly used medical treatment modality in these patients. Response rates are higher in cases without atypia. In selected cases, hysterectomy may be performed as a definitive treatment modality. In this review article current management of the endometrial hyperplasia is summarized in the light of associated literature.
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Cited by (9)
- Hyperplastic processes in the endometrium: controversial and unresolved problems of the disease 2023
- Uterine bleeding: how understanding endometrial physiology underpins menstrual health 2022
- Does Timing of Levonorgestrel Insertion in Women with Abnormal Uterine Bleeding Affect its Expulsion and Bleeding Pattern? A Follow-Up Study 2022
- Markers of menstrual flow in the diagnosis of endometrial pathology 2022
- Risk of More Advanced Lesions at Hysterectomy after Initial Diagnosis of Non-Atypical Endometrial Hyperplasia in Patients with Postmenopausal Bleeding and Oral Anticoagulant Treatment 2021
- Predicting the risk of malignisation of endometrial hyperplasia in reproductive age 2020
- Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma 2019
- Clinicopathologic Aspects of Endometrial Proliferous Processes in Women of Reproductive Age 2017
- Premenopausal abnormal uterine bleeding and risk of endometrial cancer 2016
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:08:04.945943+00:00
License: CC0
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