Gonadotropin releasing hormone agonist therapy and its effect on bone mass

T Nencioni, Nencioni T, M Penotti, Penotti M, M. Barbieri-Carones, Barbieri-Carones M, S. Ortolani, Ortolani S, C. Trevisan, Polvani F, F Polvani
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 1991 · vol. 5(1) , pp. 49–56 · doi:10.3109/09513599109049941 · PMID:1910246 · W2136328742
Non-randomised trial OA: closed CC0 ⤵ 10 in-corpus citations
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Six months of gonadotropin releasing hormone agonist therapy in patients with endometriosis or uterine fibroids significantly decreased bone mineral density at both lumbar spine and forearm sites.

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Abstract

The effects on bone mass of a 6 month therapeutic cycle with a gonadotropin releasing hormone agonist (GnRHa) were studied in 22 patients, ten affected by pelvic endometriosis and 12 by uterine fibroids. All patients were subjected to preliminary full examinations to confirm their diagnosis (laparoscopy for the endometriosis group and precise ultrasound volume measurements for uterine fibroids group). Before the beginning of treatment, bone mineral density (BMD) was measured in each patient both on the distal third of the forearm, with single-photon absorptiometry, and on the lumbar spine (L1-L4), with dual photon absorptiometry. The gonadotropin releasing hormone agonist used was buserelin. In the first week of therapy 0.5 mg of the drug was administered subcutaneously thrice daily. In the following 25 weeks the same drug was given intranasally, at a dosage of 300 micrograms again three times a day. Bone mass measurements, both at the peripheral and at the axial site, were repeated at the end of the 26-week therapeutic cycle and then again 6 months later. At the 26th week, a significant decrease of BMD was observed at both sites. The loss was 1.5% (p less than 0.05) on the lumbar spine, and 2.1% (p less than 0.05) on the radius. No bone mass restoration took place in the following 6 months. On the contrary, a less significant but discernible trend towards a further bone loss was apparent in the BMD values measured 6 months after the end of therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

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Condition tags

endometriosis

MeSH descriptors

Bone Density Buserelin Adult Adult Amenorrhea Amenorrhea Amenorrhea Bone Density Bone Density Buserelin Buserelin Buserelin Endometriosis Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Female

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