Effect of Treatment with GnRH Agonists on New Markers of Bone Metabolism

A Kukuvitis, Asterios Kukuvitis, Kukuvitis A, J. Bildiris, Bildiris J, Yannis Prapas, Y Prapas, Prapas Y, Tsamis D, D Tsamis, J. Papadimas, Papadimas J, A Dimitriadou, Dimitriadou A, Vlassis G, G. Vlassis
Gynecologic and obstetric investigation · 1999 · vol. 47(3) , pp. 194–196 · doi:10.1159/000010093 · PMID:10087416 · W2028880566
article OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study found that urinary N-telopeptides increased by 44% and bone-specific alkaline phosphatase increased by 40% after 3 months of GnRH agonist treatment in women, indicating increased bone resorption and formation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

To assess the utility of new markers in monitoring bone turnover during treatment with GnRH agonists, alkaline phosphatase (total and bone specific) and urinary N-telopeptides were measured. 16 women undergoing treatment with GnRH agonists for endometriosis or leiomyomas were studied before and 3 months after the onset of treatment. N-telopeptide levels increased significantly (44% of baseline, p < 0.05). Bone specific alkaline phosphatase (BALP), measured with a new ELISA assay, was more elevated (40% of baseline, p = 0.001) than total ALP (15% of baseline, p < 0.001). In conclusion, in estrogen deficiency states, urinary N-telopeptide measurements provide a quantitative measure of bone resoption. In the assessment of bone formation, BALP determination is move sensitive than total ALP and this may be clinically useful.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Biomarkers Bone and Bones Endometriosis Gonadotropin-Releasing Hormone Leiomyoma Uterine Neoplasms Alkaline Phosphatase Alkaline Phosphatase Biomarkers Bone and Bones Bone and Bones Bone Remodeling Bone Remodeling Calcium Calcium Collagen Collagen Collagen Type I Endometriosis Estradiol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (1)

Source provenance

europepmc
last seen: 2026-09-03T06:15:13.668130+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:29.640636+00:00
unpaywall
last seen: 2026-09-03T06:36:50.994332+00:00
License: CC0 · commercial use OK