Effect of treatment with GnRH agonists on new markers of bone metabolism

A Kukuvitis, Asterios Kukuvitis, Kukuvitis A, J. Bildiris, Bildiris J, Yannis Prapas, Y Prapas, Prapas Y, Tsamis D, D Tsamis, J. Papadimas, Papadimas J, A Dimitriadou, Dimitriadou A, Vlassis G, G. Vlassis
Gynecologic and obstetric investigation · 1999 · vol. 47(3) , pp. 194–196 · doi:10.1159/000010093 · PMID:10087416 · W2028880566
Non-randomised trial OA: closed CC0 ⤵ 1 in-corpus citation
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This study found that urinary N-telopeptides increased by 44% and bone-specific alkaline phosphatase increased by 40% after 3 months of GnRH agonist treatment in women, indicating increased bone resorption and formation.

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Abstract

To assess the utility of new markers in monitoring bone turnover during treatment with GnRH agonists, alkaline phosphatase (total and bone specific) and urinary N-telopeptides were measured. 16 women undergoing treatment with GnRH agonists for endometriosis or leiomyomas were studied before and 3 months after the onset of treatment. N-telopeptide levels increased significantly (44% of baseline, p < 0.05). Bone specific alkaline phosphatase (BALP), measured with a new ELISA assay, was more elevated (40% of baseline, p = 0.001) than total ALP (15% of baseline, p < 0.001). In conclusion, in estrogen deficiency states, urinary N-telopeptide measurements provide a quantitative measure of bone resoption. In the assessment of bone formation, BALP determination is move sensitive than total ALP and this may be clinically useful.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Bone and Bones Endometriosis Gonadotropin-Releasing Hormone Leiomyoma Uterine Neoplasms Alkaline Phosphatase Alkaline Phosphatase Alkaline Phosphatase Biomarkers Biomarkers Bone and Bones Bone and Bones Bone and Bones Bone Remodeling Bone Remodeling Bone Remodeling Calcium Calcium Calcium

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