Gynaecological uses of a new class of steroids: the selective progesterone receptor modulators

Axelle Pintiaux, Nathalie Chabbert‐Buffet, Jean‐Michel Foidart
In: Gynecological Endocrinology · 2009 · vol. 25(2) , pp. 67–73 · doi:10.1080/09513590802531120 · PMID:19253100 · W1990206758
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review evaluates the current and potential gynecological applications of selective progesterone receptor modulators, a new class of synthetic steroids that interact with the progesterone receptor to produce varied effects.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This 2009 review evaluates the actual and potential usefulness of selective progesterone receptor modulators (SPRM), a class of synthetic steroids that bind the progesterone receptor and can produce agonist, antagonist, or mixed effects across progesterone target tissues in vivo. It surveys how SPRMs could be used in gynecology, referencing key applications such as contraception and therapeutic abortion, and also discussing relevance to conditions like endometriosis and uterine myoma. A stated limitation of a review is that it synthesizes existing evidence rather than presenting new experimental or trial data. This paper is centrally about endometriosis — it discusses SPRMs as a therapeutic option for endometriosis among broader gynecologic uses.

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Abstract

Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on various progesterone target tissues in vivo. This review evaluates the actual and potential usefulness of SPRMs in gynaecology.
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Keywords

SPRM; progesterone; progesterone receptor; contraception; therapeutic abortion; endometriosis; myoma; woman; human

Abstract

[en] Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on various progesterone target tissues in vivo. This review evaluates the actual and potential usefulness of SPRMs in gynaecology Disciplines : Reproductive medicine (gynecology, andrology, obstetrics) Chabbert-Buffet, N. Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement Language : English Title : Gynaecological uses of a new class of steroids: the selective progesterone receptor modulators Publication date : 2009 Journal title : Gynecological Endocrinology ISSN : 0951-3590 eISSN : 1473-0766 Publisher : Taylor & Francis, London, United Kingdom Volume : 25 Issue : 2 Pages : 67-73 Peer reviewed : Peer Reviewed verified by ORBi Available on ORBi : since 22 June 2009 Scopus citations® 10 Scopus citations® without self-citations without self-citations 10 OpenCitations 8 OpenAlex citations 11 - Chwalisz K, Perez MC, DeManno D, Winkel C, Schubert G, Elger W. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Endocr Rev 2005;26:423-438. - Philibert D. RU38486: an original multifacted antihormone in vivo. In: Agarwal M, editor. 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