Clinical applications of mifepristone

Oi Shan Tang, Pak Chung Ho
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2006 · vol. 22(12) , pp. 655–659 · doi:10.1080/09513590601005946 · PMID:17162706 · W1984252593
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Mifepristone, a progesterone antagonist, is an effective abortifacient, cervical priming agent, and emergency contraceptive, with explored applications in fibroids, endometriosis, and cancer, though its abortion association limits broader use.

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Abstract

Mifepristone is a progesterone antagonist that has been studied for a number of clinical applications. It is a well-known abortifacient that is effective for both first- and second-trimester medical abortion when used with a prostaglandin analog. It is also an effective cervical priming agent that can be used to soften the cervix before surgical evacuation. Its clinical efficacy as an emergency contraception has been proven. Other applications including treatment for fibroids, endometriosis and various cancers have been explored. However, its association with abortion limits the applications of mifepristone in many of these areas.

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Condition tags

endometriosis

MeSH descriptors

Abortifacient Agents, Steroidal Abortion, Induced Mifepristone Abortifacient Agents, Steroidal Abortifacient Agents, Steroidal Abortion, Induced Abortion, Spontaneous Abortion, Spontaneous Contraceptive Agents Contraceptive Agents Contraceptive Agents Female Genital Diseases, Female Genital Diseases, Female Humans Mifepristone Mifepristone Pregnancy

Citation neighborhood

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References (51)

Cited by (6)

Source provenance

europepmc
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