High-intensity focused ultrasound in the management of adenomyosis: long-term results from a single center

Li X, Xilei Li, Xiaogang Zhu, Zhu X, Sili He, He S, Zhaoying Jiang, Jiang Z, Li H, Huihua Li, Tian X, Xingbo Tian, Long W, Wenxin Long, Xue M, Min Xue, Deng X, Xinliang Deng, Ye M, Mingzhu Ye
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021 · vol. 38(1) , pp. 241–247 · doi:10.1080/02656736.2021.1886347 · PMID:33602049 · W3129863418
article OA: gold CC0 ⤵ 28 in-corpus citations
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

This study analyzed long-term outcomes in 1982 adenomyosis patients treated with high-intensity focused ultrasound (HIFU), finding it safe and effective, with combined Mirena or GnRH-a/Mirena treatments showing superior sustained results.

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Abstract

Objective To investigate the long-term clinical outcomes of patients with adenomyosis treated by high-intensity focused ultrasound (HIFU).Materials and methods From June 2012 to January 2020, 2311 patients with adenomyosis were treated with HIFU at our center, 1982 patients who have complete clinical data were retrospectively reviewed. Among the patients who completed the follow-up, 485 were treated with HIFU alone, 289 were treated with HIFU followed by GnRH-a, 255 were treated with HIFU combined with Mirena and 594 were treated with HIFU combined with GnRH-a and Mirena. The dysmenorrhea severity pain score and average menorrhagia severity score before and at 3 months, 6 months, 1 year, 2 years, 3 years and 5 years after HIFU were compared. The adverse effects were recorded. In addition, the efficacy between patients treated with GnRH-a and/or Mirena were compared.Results After HIFU ablation, the dysmenorrhea severity pain score and the menorrhagia severity score were significantly decreased at each follow-up time point. However, it was observed that as the follow-up time increased, the effective rate of HIFU treatment in improving dysmenorrhea and menorrhagia decreased. The 6 months and 3 years follow-up results showed that the efficacy of HIFU combined with Mirena and HIFU combined with GnRH-a and Mirena were significantly higher than HIFU alone and HIFU combined with GnRH-a (p < 0.05). The major complications were rare.Conclusion HIFU is a safe and effective treatment for patients with adenomyosis. HIFU combined with Mirena or HIFU combined with GnRH-a and Mirena can significantly enhance the long-term treatment results.

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Condition tags

dysmenorrheaadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis High-Intensity Focused Ultrasound Ablation Menorrhagia Dysmenorrhea Female Humans Retrospective Studies Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (30)

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