Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle

Hugo Maia, Kleber Pimentel, Tânia M. Correia Silva, Luiz Antônio Rodrigues de Freitas, Luíz A R Freitas, Bela Zausner, Célia Athayde, Elsimar Metzker Coutinho, Elsimar M Coutinho
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2006 · vol. 22(4) , pp. 219–224 · doi:10.1080/09513590600585955 · PMID:16723309 · W2143778718
Observational OA: green CC0 ⤵ 20 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Endometrial polyps showed significantly higher aromatase expression than disease-free endometrium, while COX-2 and Ki-67 expression patterns during the menstrual cycle were similar in both groups.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVES: To study the changes in aromatase, Ki-67 and cyclooxygenase-2 (COX-2) expression during the menstrual cycle in both endometrial polyps and normal endometria. PATIENTS AND METHODS: Paraffin-embedded tissue samples from 118 premenopausal patients were submitted to immunohistochemistry for measurement of aromatase, COX-2 and Ki-67 expression. Fifty cases of endometrial polyps and 68 cases of disease-free endometrium were included. RESULTS: The presence of aromatase expression was significantly higher in endometrial polyps than in disease-free endometria. On the other hand, changes in COX-2 and Ki-67 expression followed a similar pattern during the menstrual cycle in both groups, expression peaking during the proliferative phase and falling during the late luteal phase. CONCLUSION: A significantly higher proportion of endometrial polyps express aromatase compared with disease-free endometrium; however, no correlation was found between aromatase expression and changes in either Ki-67 or COX-2 expression during the menstrual cycle.

My notes (saved in your browser only)

MeSH descriptors

Aromatase Cyclooxygenase 2 Endometrium Ki-67 Antigen Polyps Adult Aromatase Chi-Square Distribution Cyclooxygenase 2 Endometrium Endometrium Female Humans Immunohistochemistry Ki-67 Antigen Menstrual Cycle Menstrual Cycle Middle Aged Polyps Retrospective Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (17)

Cited by (19)

Source provenance

openalex
last seen: 2026-05-11T06:08:11.709964+00:00
pubmed
last seen: 2026-10-08T21:03:51.313027+00:00
License: CC0 · commercial use OK