Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle

Hugo Maia, Kleber Pimentel, Tânia M. Correia Silva, Luiz Antônio Rodrigues de Freitas, Bela Zausner, Célia Athayde, Elsimar Metzker Coutinho
In: Gynecological Endocrinology · 2006 · vol. 22(4) , pp. 219–224 · doi:10.1080/09513590600585955 · PMID:16723309 · W2143778718
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Endometrial polyps showed significantly higher aromatase expression than disease-free endometrium, while COX-2 and Ki-67 expression patterns during the menstrual cycle were similar in both groups.

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Abstract

OBJECTIVES: To study the changes in aromatase, Ki-67 and cyclooxygenase-2 (COX-2) expression during the menstrual cycle in both endometrial polyps and normal endometria. PATIENTS AND METHODS: Paraffin-embedded tissue samples from 118 premenopausal patients were submitted to immunohistochemistry for measurement of aromatase, COX-2 and Ki-67 expression. Fifty cases of endometrial polyps and 68 cases of disease-free endometrium were included. RESULTS: The presence of aromatase expression was significantly higher in endometrial polyps than in disease-free endometria. On the other hand, changes in COX-2 and Ki-67 expression followed a similar pattern during the menstrual cycle in both groups, expression peaking during the proliferative phase and falling during the late luteal phase. CONCLUSION: A significantly higher proportion of endometrial polyps express aromatase compared with disease-free endometrium; however, no correlation was found between aromatase expression and changes in either Ki-67 or COX-2 expression during the menstrual cycle.

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