Effect of disease-modifying anti-rheumatic drugs on therapeutic outcomes among women with endometriosis

Kotlyar A, Alexander Kotlyar, Shirley Shue, Shue S, Xiaobo Liu, Liu X, Falcone T, Tommaso Falcone
International Journal of Gynecology & Obstetrics · 2017 · vol. 141(2) , pp. 228–233 · doi:10.1002/ijgo.12416 · PMID:29205346 · W2773527915
Observational OA: closed CC0 ⤵ 4 in-corpus citations
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This retrospective study found that disease-modifying anti-rheumatic drug use for at least six weeks was associated with decreased opioid usage in women with endometriosis.

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Abstract

OBJECTIVE: To determine whether disease-modifying anti-rheumatic drugs (DMARDs) affect the use of hormonal treatments, subsequent ablative surgery, and need for pain management, including opioids, non-steroidal anti-inflammatory drugs and anti-depressants, among women with endometriosis. METHODS: In a retrospective study, data were reviewed from women with surgically confirmed endometriosis who were not treated (n=234) or treated with DMARDs for 6 weeks or more (n=25) before surgical diagnosis at a single healthcare system in the USA between 2003 and 2013. The postoperative use of hormonal treatments, proportion of women undergoing subsequent ablative surgery, and use of adjunct therapies such as antidepressants, steroids, and opioids after surgery were compared between the two groups. RESULTS: The two groups showed differences in age (P=0.007) and follow-up time (P<0.001). Univariate analysis showed more frequent use of hormonal treatments (P=0.045) and antidepressants (P=0.006) among women treated with DMARDs. The frequency of post-diagnostic use of opioids was lower among treated women (P=0.001); this association remained significant in multivariate analysis controlling for potential confounders (P=0.003). CONCLUSION: The findings suggest that administration of DMARDs for at least 6 weeks is associated with decreased opioid usage among women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Endometriosis Adult Adult Analgesics, Opioid Analgesics, Opioid Analgesics, Opioid Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Antirheumatic Agents Endometriosis Endometriosis Female Female Humans Humans Middle Aged Middle Aged

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (4)

SciLite annotations

chemicals 2
steroid opioid analgesic

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