Endometrial lesions in patients undergoing tamoxifen therapy
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AI-generated summary
Hysteroscopy of 46 breast cancer patients on tamoxifen revealed endometrial polyps, hyperplasia, or adenocarcinoma in 23, with lesion rates correlating to cumulative tamoxifen dose.
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Abstract
Forty-six nonhysterectomized women treated with tamoxifen during 6-36 months as adjuvant therapy for breast cancer underwent a hysteroscopy to assess the endometrial effects of this drug. Whereas the endometrium was normal among 23 patients, 13 presented with endometrial polyps, 8 with hyperplasia and 2 with adenocarcinoma. The rate of endometrial lesions was directly related to the cumulative dose of tamoxifen but it was not statistically different among patients receiving progestational therapy compared to patients who did not receive this therapy.
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Cited by (8)
- Benign endometrial adenofibroma and polyp in patients receiving tamoxifen: findings on transvaginal ultrasonography and magnetic resonance imaging 2005
- Adenomatous polyp--cause of postmenopausal bleeding in a breast cancer patient treated with tamoxifen 2003
- Imaging the endometrium: disease and normal variants 2001
- Tamoxifen treatment and gynecologic side effects: a review 2001
- Magnetic Resonance Imaging Versus Ultrasound in the Assessment of Benign Uterine Lesions 1998
- III.1 Tamoxifen and the uterus—the hysteroscopic approach 1998
- Benign Diseases of the Endometrium 1994
- Uterine leiomyomata and endometrial proliferation in postmenopausal women treated with the anti-oestrogen tamoxifen 1994
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:03:51.313027+00:00
- unpaywall
- last seen: 2026-10-14T06:23:58.021457+00:00
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