Benign endometrial adenofibroma and polyp in patients receiving tamoxifen: findings on transvaginal ultrasonography and magnetic resonance imaging

Akiko Ikuta, Yoshiaki Tanaka, Tomomi Mizokami, Akihiro Tsutsumi, Masahiro Sato, Maki Tanaka, Hideharu Kanzaki
In: Journal of Medical Ultrasonics · 2005 · vol. 32(2) , pp. 71–76 · doi:10.1007/s10396-005-0036-0 · W1980117810
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Transvaginal ultrasonography and magnetic resonance imaging revealed endometrial thickening and small cysts in two postmenopausal women receiving tamoxifen, with pathology confirming an adenofibroma in one case and an endometrial polyp in the other.

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Abstract

Tamoxifen, a selective estrogen receptor modulator, is widely used to treat breast cancer, but an association has been reported between tamoxifen and the development of endometrial lesions, including endometrial carcinoma, endometrial polyps, and endometrial hyperplasia. There have also recently been a few reports on the relation between tamoxifen and adenofibroma. We present two case reports, one of a patient with a uterine adenofibroma and one of a patient with an endometrial polyp, both of whom received tamoxifen. Cases 1 and 2 are 75- and 65-year-old postmenopausal women, respectively, undergoing tamoxifen therapy. In both cases, endometrial thickening and many small cysts in the uterine cavity were revealed by transvaginal ultrasonography or magnetic resonance imaging. Postoperative microscopic examination confirmed the mass as an adenofibroma in case 1 and as an endometrial polyp in case 2.

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