XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis

Hsieh YY, Yao‐Yuan Hsieh, Yao-Yuan Hsieh, DA-Tian Bau, Bau DT, Da‐Tian Bau, Chi‐Chen Chang, Chang CC, Chi-Chen Chang, Chang-Hai Tsai, Chang‐Hai Tsai, Tsai CH, Chih-Ping Chen, Chih‐Ping Chen, Chen CP, Fuu‐Jen Tsai, Tsai FJ, Fuu-Jen Tsai
Molecular reproduction and development · 2008 · vol. 75(5) , pp. 946–951 · doi:10.1002/mrd.20829 · PMID:18246529 · W2079231747
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XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes are associated with increased endometriosis susceptibility, unlike the XRCC4 intron 3 polymorphism.

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Abstract

DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. Genetic variants in DNA repair genes such as X-ray repair cross-complementing group 4 (XRCC4) might influence the ability to repair damaged DNA. Herein we aimed to investigate whether some XRCC4-related polymorphisms were associated with endometriosis susceptibility. Women were divided: (1) severe endometriosis (rAFS stage IV, n = 136) and (2) nonendometriosis groups (n = 112). The polymorphisms of XRCC4 codon 247, XRCC4 promoter -1394, and XRCC4 intron 3 insertion/deletion (I/D) polymorphism were amplified by PCR and detected by electrophoresis after restriction enzyme (BBS I, Hinc II) digestions. Genotypes and allelic frequencies in both groups were compared. We observed that XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes, but not XRCC4 intron 3 I/D polymorphism, are associated with higher susceptibility for endometriosis. Distributions of XRCC4 codon 247*C homozygote/heterozygote/A homozygote, and C/A allele in both groups were: (1) 89/9.5/1.5% and 93.7/6.3%; (2) 97.3/2.7/0%, and 98.7/1.3% (P < 0.05). Proportions of XRCC4 promoter -1394*T homozygote/heterozygote/G homozygote and T/G allele in both groups were: (1) 94.1/5.2/0.7% and 96.7/3.3%, and (2) 79.4/17.9/2.7% and 88.4/11.6% (P < 0.005). Proportions of XRCC4*I homozygote/heterozygote/D homozygote and A/C allele in both groups were: (1) 67.6/30.9/1.5% and 83.2/16.8%, and (2) 70.5/24.1/5.4% and 82.6/17.4% (nondifference). We conclude that XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes and alleles, but not XRCC4 intron 3 I/D polymorphism, might be associated with endometriosis susceptibilities and pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Codon DNA-Binding Proteins Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease INDEL Mutation INDEL Mutation Introns Polymorphism, Genetic Polymorphism, Genetic Promoter Regions, Genetic Alleles Alleles Asian People Asian People Codon Codon DNA-Binding Proteins DNA-Binding Proteins DNA Damage

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