Remarkable Response of Primary Squamous Cell Carcinoma of the Ovary to Paclitaxel and Cisplatin

G Eltabbakh, Eltabbakh GH, G H Eltabbakh, R E Hempling, Hempling RE, Recio FO, F O Recio, C P O'Neill, O'Neill CP
Obstetrics and gynecology · 1998 · vol. 91(5) , pp. 844–846 · doi:10.1016/s0029-7844(97)00665-0 · PMID:9572185 · W2055405051
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A patient with stage IV primary ovarian squamous cell carcinoma and hepatic metastases experienced a dramatic response and remains disease-free for 2 years after cytoreductive surgery followed by paclitaxel and cisplatin chemotherapy.

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Abstract

BACKGROUND: The survival rate of patients with advanced stage primary squamous cell carcinoma of the ovary is dismal and the best treatment is unknown. We describe the response of this tumor to systemic chemotherapy employing paclitaxel and cisplatin. CASE: A 31-year-old white woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary squamous cell carcinoma of the ovary associated with ovarian endometriosis underwent cytoreductive surgery followed by paclitaxel and cisplatin every 4 weeks for 12 courses. The patient tolerated chemotherapy well, demonstrated a dramatic response with disappearance of hepatic metastases, and remains without evidence of disease 2 years after diagnosis. CONCLUSION: Paclitaxel and cisplatin may be effective in treating primary squamous cell carcinoma of the ovary.

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Condition tags

endometriosis

MeSH descriptors

Antineoplastic Combined Chemotherapy Protocols Carcinoma, Squamous Cell Ovarian Neoplasms Adult Antineoplastic Combined Chemotherapy Protocols Carcinoma, Squamous Cell Carcinoma, Squamous Cell Carcinoma, Squamous Cell Cisplatin Cisplatin Combined Modality Therapy Female Humans Liver Neoplasms Liver Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Paclitaxel Paclitaxel

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