De novo Ovarian Squamous Cell Carcinoma. A Case Report and Review of Literature

P. N. Shakuntala, Shakuntala PN, V. R. Pallavi, Pallavi VR, Meenakshi S, S. Meenakshi, M. Anil, Anil M, K Umadevi, Umadevi K, Bafna UD, U. D. Bafna
Indian journal of surgical oncology · 2013 · vol. 4(3) , pp. 269–271 · doi:10.1007/s13193-013-0236-9 · PMID:24426735 · PMC3771055 · W2026631241
article OA: bronze CC0 ⤵ 1 in-corpus citation
📄 Open PDF Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-07-23 ⓘ

This case report presents and reviews literature on de novo ovarian squamous cell carcinoma, a rare malignancy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-04 · read from full text ⓘ

This case report and literature review describes a rare instance of de novo primary ovarian squamous cell carcinoma, emphasizing its aggressive clinical course and poor response to standard chemotherapy regimens like paclitaxel and carboplatin. The authors analyze existing literature to highlight that while most primary ovarian squamous cell carcinomas arise from mature cystic teratomas or endometriosis, true de novo cases are exceptionally uncommon and often resistant to conventional platinum-based treatments. The paper notes significant diagnostic challenges due to the tumor's rarity and lack of specific biomarkers, leading to delayed diagnosis and limited therapeutic options for patients. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 2,999 characters · extracted from oa-doi-fallback · 2 sections · click to expand

References

Clement PB, Young RH (2010) Ovarian surface epithelial-stromal tumors. In: Mills SE, Carter D, Greenson JK et al (eds) Sternberg’s diagnostic surgical pathology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 2278–2341 Dos Santos L, Mok E, Iasonos A, Park K, Soslow RA, Aghajanian C et al (2007) Squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literature. Gynecol Oncol 105:321–324 Pins MR, Young RH, Daly WJ, Scully RE (1996) Primary squamous cell carcinoma of the ovary. Report of 37 cases. Am J Surg Pathol 20:823–833 Naresh KN, Ahuja VK, Rao CR, Mukherjee G, Bhargava MK (1991) Squamous cell carcinoma arising in endometriosis of the ovary. J Clin Pathol 44:958–959 Chien SC, Sheu BC, Chang WC, Wu MZ, Huang SC (2005) Pure primary squamous cell carcinoma of the ovary: a case report and review of the literature. Acta Obstet Gynecol Scand 84:706–708 Todo Y, Minobe S, Sasaki M, Yamamoto R, Sakuragi N (2005) A case of pure-type ovarian squamous cell carcinoma for which combination chemotherapy consisting of paclitaxel and carboplatin was not effective. Gynecol Oncol 97(1):223–227 Amjad AI, Pal I (2008) De novo primary squamous cell carcinoma of the ovary: a case of a rare malignancy with an aggressive clinical course. J Pak Med Assoc 58(5):273 Park J-Y, Song JS, Choi G, Kim J-H, Nam J-H (2010) Pure primary squamous cell carcinoma of the ovary: a report of two cases and review of the literature. Int J Gynecol Pathol 29(4):328–334 Yamakawa Y, Ushijima M, Kato K (2011) Primary squamous cell carcinoma associated with ovarian endometriosis: a case report and literature review. Int J Clin Oncol 16(6):709–713, Epub 2011 Feb 8 Mahe E, Sur M (2011) Primary squamous cell carcinoma of the ovary. MUMJ 8(1):80–83 Acién P, Abad M, Mayol M, Garcia S, Garde J (2010) Primary squamous cell carcinoma of the ovary associated with endometriosis. Int J Gynecol Obstet 108:16–20 Eltabbakh GH, Hempling RE, Recio FO, O’Neill CP (1998) Remarkable response of primary squamous cell carcinoma of the ovary to paclitaxel and cisplatin. Obstet Gynecol 91(5 II suppl):844–846 Ohtani K, Sakamoto H, Masaoka N, Shimada K, Kanaeda T, Kurihara M et al (2000) A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration. Gynecol Oncol 79:515–518

Acknowledgement

We would like to thank all the members of Department of Radiotherapy for their inputs in patient care. We appreciate the nursing care given by our OT, ICU and ward staffs . Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Shakuntala, P.N., Pallavi, V.R., Meenakshi, S. et al. De novo Ovarian Squamous Cell Carcinoma. A Case Report and Review of Literature. Indian J Surg Oncol 4, 269–271 (2013). https://doi.org/10.1007/s13193-013-0236-9 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s13193-013-0236-9

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

Cited by (1)

References (15)

Cited by (1)

Source provenance

europepmc
last seen: 2026-09-13T09:25:22.628771+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK