Pure Primary Squamous Cell Carcinoma of the Ovary: A Report of Two Cases and Review of the Literature

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This report details two rare cases of pure primary ovarian squamous cell carcinoma and reviews literature indicating poor survival outcomes for advanced-stage tumors despite multimodal treatment.

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Abstract

Pure primary squamous cell carcinoma (SCCa) of the ovary not associated with pre-existing ovarian lesions including dermoid cysts, Brenner tumors, or endometriosis is extremely rare. The last 2 types of SCCa and pure primary SCCa have been classified by the World Health Organization criteria as surface epithelial-stromal tumors. On account of the rarity of pure primary SCCa of the ovary, the clinical features and effective treatments have not been established. This study describes 2 such cases that we recently encountered in a review of the literature. The literature shows that patients with advanced-stage tumors have very poor survival outcomes, despite a combination of surgery, radiation therapy, and chemotherapy.
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PATHOLOGY OF THE UPPER GENITAL TRACT: CASE REPORTS Pure Primary Squamous Cell Carcinoma of the Ovary: A Report of Two Cases and Review of the Literature - Jeong-Yeol Park - Joon Seon Song - Gawon Choi - Jong-Hyeok Kim - Joo-Hyun Nam International Journal of Gynecological Pathology 29(4):p 328-334, July 2010. | DOI: 10.1097/PGP.0b013e3181c6d965 Pure primary squamous cell carcinoma (SCCa) of the ovary not associated with pre-existing ovarian lesions including dermoid cysts, Brenner tumors, or endometriosis is extremely rare. The last 2 types of SCCa and pure primary SCCa have been classified by the World Health Organization criteria as surface epithelial-stromal tumors. On account of the rarity of pure primary SCCa of the ovary, the clinical features and effective treatments have not been established. This study describes 2 such cases that we recently encountered in a review of the literature. The literature shows that patients with advanced-stage tumors have very poor survival outcomes, despite a combination of surgery, radiation therapy, and chemotherapy. Copyright ©2010International Society of Gynecological Pathologists

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Squamous Cell Ovarian Neoplasms Aged Carcinoma, Squamous Cell Carcinoma, Squamous Cell Carcinoma, Squamous Cell Female Histocytochemistry Humans Middle Aged Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms

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