Bilateral Primary Ovarian Squamous Cell Carcinoma Associated with Human Papilloma Virus Infection and Vulvar and Cervical Intraepithelial Neoplasia

Kien T. Mai, K T Mai, T. Kien, Mai KT, Hossein M. Yazdi, Yazdi HM, H M Yazdi, Bertrand MA, M A Bertrand, Monique Bertrand, Nicole LeSaux, N LeSaux, LeSaux N, Linda L. Cathcart, Cathcart LL, L L Cathcart
The American journal of surgical pathology · 1996 · vol. 20(6) , pp. 767–772 · doi:10.1097/00000478-199606000-00016 · PMID:8651358 · W2014459552
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper reports a primary ovarian squamous cell carcinoma associated with HPV 16/18, vulvar intraepithelial neoplasia, and cervical intraepithelial neoplasia in a 40-year-old woman.

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Abstract

Primary squamous cell carcinoma of the ovary is rare. Most cases represent malignant transformation of ovarian teratomas. Other cases are associated with preexisting Brenner tumor or ovarian endometriosis. We report a primary ovarian squamous cell carcinoma in a 40-year-old woman. The patient had recurrent high-grade intraepithelial neoplasia of the vulva (VIN) and recurrent high-grade cervical intraepithelial neoplasia (CIN). Human papilloma virus (HPV) DNA 16/18 was identified in an in situ and invasive carcinoma in the left ovary; CIN and VIN were identified with in situ hybridization with biotinylated DNA probes. Review of the literature revealed nine cases of primary ovarian squamous cell carcinoma not associated with a preexisting ovarian lesion. Three cases were not associated with CIN and occurred in women who ranged in age from 64 to 90 years and did not have carcinoma in situ component. Six cases were associated with CIN, had a carcinoma in situ, and occurred in younger women ranging from 33 to 54 years of age. Our case belonged to the latter category. This report raises the possible causal relationship of HPV with primary ovarian squamous carcinoma in the group of middle-aged patients with CIN.
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Bilateral Primary Ovarian Squamous Cell Carcinoma Associated with Human Papilloma Virus Infection and Vulvar and Cervical Intraepithelial Neoplasia A Case Report with Review of the Literature - Kien T. Mai - Hossein M. Yazdi - Monique A. Bertrand - Nicole LeSaux - Linda Cathcart Primary squamous cell carcinoma of the ovary is rare. Most cases represent malignant transformation of ovarian teratomas. Other cases are associated with preexisting Brenner tumor or ovarian endometriosis. We report a primary ovarian squamous cell carcinoma in a 40-year-old woman. The patient had recurrent high-grade intraepithelial neoplasia of the vulva (VIN) and recurrent high-grade cervical intraepithelial neoplasia (CIN). Human papilloma virus (HPV) DNA 16/18 was identified in an in situ and invasive carcinoma in the left ovary; CIN and VIN were identified with in situ hybridization with biotinylated DNA probes. Review of the literature revealed nine cases of primary ovarian squamous cell carcinoma not associated with a preexisting ovarian lesion. Three cases were not associated with CIN and occurred in women who ranged in age from 64 to 90 years and did not have carcinoma in situ component. Six cases were associated with CIN, had a carcinoma in situ, and occurred in younger women ranging from 33 to 54 years of age. Our case belonged to the latter category. This report raises the possible causal relationship of HPV with primary ovarian squamous carcinoma in the group of middle-aged patients with CIN.

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Condition tags

endometriosis

MeSH descriptors

Neoplasms, Multiple Primary Ovarian Neoplasms Papillomaviridae Uterine Cervical Neoplasms Vulvar Neoplasms Adult Carcinoma in Situ Carcinoma in Situ Carcinoma in Situ Carcinoma, Squamous Cell Carcinoma, Squamous Cell Carcinoma, Squamous Cell Female Humans Neoplasms, Multiple Primary Neoplasms, Multiple Primary Ovarian Neoplasms Ovarian Neoplasms Papillomaviridae Papillomavirus Infections

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References (22)

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