Moderate-Severe Endometriosis Shows Higher CA-125 Serum Level Compared to Minimal-Mild Endometriosis
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This study found that moderate-severe endometriosis patients exhibited higher serum CA-125 levels compared to those with minimal-mild endometriosis.
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Abstract
Objective: To investigate and compare serum profile of CA-125, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in various stages of endometriosis.
Methods: Forty endometriosis patients’ blood samples were taken prior to laparoscopic surgery for various indications. Diagnosis of endometriosis was confirmed by laparoscopy. Independent T test methods were used for statistical analysis. ROC analysis was examined for each variable.
Results: The mean level of CA-125 serum was 12.0 vs. 36.3 U/ml (p 0.05); CRP serum was 0.7 vs. 0.3 (p > 0.05) for endometriosis stage I-II and stage III-IV, respectively. The optimal cut off point to discriminate endometriosis
stage I-II and III-IV was 16.9 U/ml with sensitivity 83% and specificity 81%.
Conclusion: The CA-125 serum level was increased for moderatesevere compare to minimal mild endometriosis patient.
[Indones J Obstet Gynecol 2012; 36-3: 121-4]
Keyword: CA-125, CRP, endometriosis, ESR, serum
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References (14)
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