Pain in the upper anterior-lateral part of the thigh in women affected by endometriosis: study of sensitive neuropathy

Arianna Pacchiarotti, Pacchiarotti A, Milazzo GN, G. Milazzo, Giusi Natalia Milazzo, A. Biasiotta, Antonella Biasiotta, Biasiotta A, Andrea Truini, Giovanni Antonini, Paola Frati, Vincenzo Gentile, Caserta D, Donatella Caserta, Moscarini M, Massimo Moscarini
Fertility and sterility · 2013 · vol. 100(1) , pp. 122–126 · doi:10.1016/j.fertnstert.2013.02.045 · PMID:23541315 · W2041026806
Observational OA: bronze CC0 ⤵ 15 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper investigated sensitive neuropathy in women experiencing pain in the upper anterior-lateral thigh, a common symptom associated with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To assess whether pain in the anterior-lateral part of the thigh in women affected by endometriosis is due to femoral nerve invasion by endometriotic implants. DESIGN: Case-control study. SETTING: Hospital. PATIENT(S): We enrolled 30 patients with endometriosis and leg pain in the anterior-lateral part of the thigh and 30 healthy women. INTERVENTION(S): Skin biopsy and neurologic examination for detection of neuropathy. MAIN OUTCOME MEASURE(S): Intraepidermal small fiber density reduction and positive neurologic examination agree with sensitive neuropathy. RESULT(S): Biopsy results showed no statistically significant difference between the case group and the control group. At neurologic examination nine patients in the study group (30%) showed positive results, none in the control group showed signs. These nine patients had reduced intraepidermal small fiber density, compared to the lower cutoff values of the control group, suggesting a sensitive neuropathy. CONCLUSION(S): When there is leg pain in women with endometriosis it is important to distinguish neuropathic from referred pain. Skin biopsy and neurologic examination should be introduced in the management of leg pain in endometriosis, due to their low invasiveness to diagnose a sensitive neuropathy. As a result early detection of nerve injury and planning for a prompt specific treatment would be possible.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Neuralgia Neuralgia Thigh Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Humans Humans Middle Aged Middle Aged Neuralgia Neuralgia Pain

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (41)

Cited by (15)

Source provenance

europepmc
last seen: 2026-10-10T06:11:15.153948+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:11:40.903767+00:00
License: CC0 · commercial use OK