GnRH-Analoga und Add-back-Verfahren

Ñ Einleitung, J. Kleinstein
In: Journal für Gynäkologische Endokrinologie · 2008 · vol. 2(2) , pp. 40–43 · W2101860066
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GnRH analogues with add-back therapy are effective for endometriosis pain and infertility, and can be used long-term to counteract side effects like bone loss.

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Abstract

Gonadotropin Releasing Hormone Ana- logues and Add-Back Therapy. Gonadotropin re- leasing hormone analogues (GnRH-a) play a major role in the conservative therapy for endometriosis. They are a part of the therapy regime for infertility caused by endometriosis and they have the ability to reduce the pain associated with the endometriosis. Due to endometriosis being a chronic condition, a therapy using GnRH-a for more than six months is often needed. For these cases, a hormone replacement add-back therapy is needed in parallel to couteract the vasomotoric side effects and the loss of bone mass. The dosage of the estrogen part of the therapy is set within a therapeutic range and is low enough to offset the hypoestrogenism without allowing the endometriosis to advance. In prinicipal, estrogen can be administered orally or transdermally. It has been proven that the combination of GnRH-a plus the add- back therapy remains effective for up to ten years. This has provided an alternative for women who have already had multiple operations and recurring endometriosis. There are several other alternatives to the add-back therapy, but their use has shown limited effectiveness and considerable side effects. J Gynakol Endokrinol 2008; 18 (2): 40 -4 3.

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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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