MLL1:EZH2 Ratio in Uterine Secretions and Endometrial Receptivity in Patients with Endometriosis

Zou K, Kehan Zou, Qing Du, Du Q, Chen X, Xin Chen, Tang P, Pingfang Tang, Huizhen Liang
Laboratory medicine · 2022 · vol. 54(1) , pp. 90–97 · doi:10.1093/labmed/lmac067 · PMID:36094360 · W4295884785
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study established and validated the MLL1:EZH2 ratio in uterine secretions during the midsecretory phase as a highly sensitive and specific marker for diagnosing endometriosis in patients with impaired endometrial receptivity.

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Abstract

OBJECTIVE: To establish a novel approach for diagnosing endometriosis (EM) in patients with impaired endometrial receptivity. METHOD: Mixed lineage leukemia 1 (MLL1) and enhancer of zeste homolog 2 (EZH2) levels were analyzed. The MLL1:EZH2 ratio in identifying impaired endometrial receptivity has been established and validated. RESULTS: In normal endometrial tissue, the MLL1:EZH2 ratio increased significantly in the midsecretory phase, compared with that in the proliferative phase. In the midsecretory phase, the MLL1:EZH2 ratio in endometrial tissues and uterine secretions accurately identifies patients with EM who have impaired endometrial receptivity. In the validation group, the sensitivity and specificity of the MLL1:EZH2 ratio in the uterine secretions of the midsecretory phase, in diagnosing patients EM who have impaired endometrial receptivity, were 100% and 96.55%, respectively. CONCLUSIONS: The MLL1:EZH2 ratio in uterine secretions of the midsecretory phase may serve as a marker to diagnose EM in patients with impaired endometrial receptivity.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

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