Development of dysplastic mucinous epithelium from endometriosis of the appendix
Case report
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⤵ 10 in-corpus citations
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This study describes mucinous metaplasia and low-grade epithelial dysplasia within appendiceal endometriosis, suggesting the appendiceal mucosa or mucin may induce metaplasia in endometrial epithelium.
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Abstract
AIM: We report an unusual case of mucinous metaplasia and epithelial dysplasia occurring in endometriotic epithelium in the appendix.
METHODS AND RESULTS: A 39-year-old woman developed an appendiceal endometriosis in which the endometrial glands displayed extensive areas consisting of mucinous epithelium and Paneth cells. Focally the mucinous epithelium showed low-grade epithelial dysplasia. These changes occurred in portions of the endometriotic tissue closest to the appendiceal lumen. Both the intestinal and endometrial epithelial components were surrounded by typical endometrial-type stroma showing positive reactivity for oestrogen receptor.
CONCLUSIONS: Formation of the mucinous epithelium most likely represents a metaplastic process of the endometrial epithelium rather than a result of a simple 'collision' of the appendiceal and endometrial epithelium. Further support for this being a metaplastic process was the presence of glandular structures containing a mixture of mucinous cells, goblet cells, Paneth cells, ciliated and nonciliated endometrial cells, and ciliated and nonciliated mucinous cells, all showing the same positive reactivity for oestrogen receptor. The disposition of mucinous epithelium in the foci of endometriosis in this case suggests that the appendiceal mucosa or extracellular mucin may play a role as an inducer of mucinous cell metaplasia in endometriotic epithelium.
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References (6)
- Endometriosis of the appendix resulting in perforation: a case report via openalex
- Endometriosis of the appendix with decidual polyp formation: a rare cause of acute appendicitis during pregnancy via openalex
- Intussusception of the appendix: a report of three cases with different clinical and pathologic features via openalex
- Mucocele of the appendix secondary to obstruction by endometriosis via openalex
- Retention mucocele of appendix due to endometriosis via openalex
- W2035062063 via openalex
Cited by (10)
- Appendiceal perforation secondary to endometriosis with intestinal metaplasia: A case report 2023
- Appendiceal Endometriosis with Intestinal Metaplasia Mimicking Appendiceal Mucinous Neoplasm - A Case Report and a Concise Review for the Practicing Pathologist 2022
- Cecal Endometriosis With Intestinal Metaplasia Misdiagnosed as Neoplasm of the Cecum by Intraoperative Histological Examination 2017
- Appendiceal or Cecal Endometriosis With Intestinal Metaplasia 2014
- Dysplastic intestinal-type metaplasia of appendiceal endometriosis: a mimic of low grade appendiceal mucinous neoplasm 2014
- Endometriosis in appendix and adjacent caecum with intestinal gland differentiation 2013
- Intestinal metaplasia and colonization of endometriosis in a case of an appendiceal mucinous neoplasm 2012
- Colonization of intestinal endometriosis by benign colonic mucosa: a pattern potentially misdiagnosed as invasive mucinous carcinoma 2010
- Miscellaneous conditions of the appendix 2004
- Asociación de tumor carcinoide y endometriosis en el apéndice junto a endometriosis de íleon terminal 2001
Source provenance
- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T20:59:14.592962+00:00
- unpaywall
- last seen: 2026-10-15T06:24:24.424788+00:00
License: CC0
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