Development of dysplastic mucinous epithelium from endometriosis of the appendix

K T Mai, Mai, Mai KT, B F Burns, Burns, Burns BF
Histopathology · 1999 · vol. 35(4) , pp. 368–372 · doi:10.1046/j.1365-2559.1999.00732.x · PMID:10564392 · W2041287505
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This study describes mucinous metaplasia and low-grade epithelial dysplasia within appendiceal endometriosis, suggesting the appendiceal mucosa or mucin may induce metaplasia in endometrial epithelium.

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Abstract

AIM: We report an unusual case of mucinous metaplasia and epithelial dysplasia occurring in endometriotic epithelium in the appendix. METHODS AND RESULTS: A 39-year-old woman developed an appendiceal endometriosis in which the endometrial glands displayed extensive areas consisting of mucinous epithelium and Paneth cells. Focally the mucinous epithelium showed low-grade epithelial dysplasia. These changes occurred in portions of the endometriotic tissue closest to the appendiceal lumen. Both the intestinal and endometrial epithelial components were surrounded by typical endometrial-type stroma showing positive reactivity for oestrogen receptor. CONCLUSIONS: Formation of the mucinous epithelium most likely represents a metaplastic process of the endometrial epithelium rather than a result of a simple 'collision' of the appendiceal and endometrial epithelium. Further support for this being a metaplastic process was the presence of glandular structures containing a mixture of mucinous cells, goblet cells, Paneth cells, ciliated and nonciliated endometrial cells, and ciliated and nonciliated mucinous cells, all showing the same positive reactivity for oestrogen receptor. The disposition of mucinous epithelium in the foci of endometriosis in this case suggests that the appendiceal mucosa or extracellular mucin may play a role as an inducer of mucinous cell metaplasia in endometriotic epithelium.

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Condition tags

endometriosis

MeSH descriptors

Appendix Cecal Diseases Endometriosis Adult Cecal Diseases Cecal Diseases Endometriosis Endometriosis Epithelium Epithelium Epithelium Female Humans Immunohistochemistry Metaplasia Receptors, Estrogen Receptors, Estrogen

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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