Analysis of inflammatory biomarkers IL-6, vascular endothelial growth factor and matrix metalloproteinases-9 expression in endometriosis

Maofang Hua, Yuan Wang, Jun Yao, Zichun Zhu, Zhenxuan Zhu, Xiaoyun Liu, Fanfei Meng, Su Yu, ShuangHua Yu
SAGE open medicine · 2025 · vol. 13 , pp. 20503121251321625 · doi:10.1177/20503121251321625 · PMID:39990967 · W4407773147
article OA: gold CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found increased expression of IL-6, vascular endothelial growth factor, and matrix metalloproteinases-9 in eutopic endometrial tissues of endometriosis patients, with matrix metalloproteinases-9 also elevated in peripheral blood and peritoneal fluid as disease severity increased.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective: Special attention has been paid to genetic mechanisms that might have a significant impact on the context of the risk of developing endometriosis, in recent years. The study aimed to analyze the expression levels of three inflammatory biomarkers Interleukin-6 (IL-6), vascular endothelial growth factor, and matrix metalloproteinases-9, in the increased incidence of endometriosis. Methods: = 30) in Lianyungang maternal and child health hospital from January 2020 to December 2023. The expression levels of IL-6, vascular endothelial growth factor, and matrix metalloproteinases-9 genes were determined by the real-time polymerase chain reaction technique. Results: The expression levels of IL-6 and vascular endothelial growth factor gene in the peripheral blood and peritoneal fluid of these endometriosis patients were not statistically significant lower than in the control group. Besides, the significant differences were found in IL-6, vascular endothelial growth factor and matrix metalloproteinases-9 between eutopic endometrial tissues of the endometriosis group, compared to the control group; and these increased significantly with the severity of the disease. In addition, there was significant difference in the expression level of matrix metalloproteinases-9 in peripheral blood and peritoneal fluid, and the difference was statistically significant in these patients with stages III-IV, compared with these patients with stages I-II. Among them, the Revised American Society for Reproductive Medicine classification of endometriosis was used in the group of patients with endometriosis. Conclusion: These patients with endometriosis showed the significant differences in matrix metalloproteinases-9 expression in peripheral blood, peritoneal fluid, and eutopic and ectopic endometrial tissues as the condition worsens. The research suggested that the determination of matrix metalloproteinases-9 in peripheral blood has certain value in evaluating the condition of endometriosis, which might play an important role in the pathogenesis of endometriosis and be explored for postoperative recurrence monitoring.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (1)

Source provenance

europepmc
last seen: 2026-06-24T06:10:11.469335+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pmc
last seen: 2026-05-13T20:22:03.195721+00:00
pubmed
last seen: 2026-05-18T00:31:42.126672+00:00
License: CC0 · commercial use OK