Does ovulation stimulation improve fertility in women with minimal/mild endometriosis after laser laparoscopy?

Kemmann E, E Kemmann, Ekkehard Kemmann, Dolly Ghazi, Ghazi D, D Ghazi, Gregory H. Corsan, G Corsan, Corsan G, M K Bohrer, Michael Bohrer, Bohrer MK
International journal of fertility and menopausal studies · 1993 · vol. 38(1) , pp. 16–21 · PMID:8485606 · W56863781
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This retrospective analysis found that ovulation stimulation, particularly with CC/hMG/hCG or hMG/hCG protocols, significantly increased cycle fecundity in infertile women after minimal/mild endometriosis treatment.

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Abstract

Cycle fecundity was retrospectively analyzed in a group of infertile women after minimal/mild endometriosis had been treated by carbon dioxide laser laparoscopy. Patients were followed in spontaneous (observation) cycles as well as in treatment cycles using ovulation stimulation. Treatment protocols included clomiphene citrate (CC), sequential CC/human menopausal gonadotropins/human chorionic gonadotropin (CC/hMG/hCG), and hMG/hCG. Some patients who failed to conceive with ovulation stimulation protocols underwent in vitro fertilization (IVF). Eighty-nine patients were followed for a total of 605 cycles, during which 37 pregnancies occurred. Cycle fecundity was 0.028 in observation cycles, and was higher with the use of CC (0.066), and significantly higher (P < .05) with use of CC/hMG/hCG (0.114) and hMG/hCG (0.073). The highest cycle fecundity was attained in IVF cycles (0.222). This retrospective analysis suggests that active ovulation management in patients with minimal/mild endometriosis treated by carbon dioxide laser laparoscopy may significantly increase cycle fecundity.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Ovulation Induction Ovulation Induction Ovulation Induction Pregnancy Outcome Pregnancy Outcome Adult Adult Chorionic Gonadotropin Chorionic Gonadotropin Chorionic Gonadotropin Clomiphene Clomiphene Clomiphene Danazol Danazol Danazol Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (20)

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