Patients with endometriosis and patients with poor ovarian reserve have abnormal follicle-stimulating hormone receptor signaling pathways

Rebeca González-Fernández, Óscar Peña, Peña Ó, Hernández J, Jairo Hernández, Pablo Martín-Vasallo, Pablo Martı́n-Vasallo, Angela Palumbo, Julio Ávila
Fertility and sterility · 2011 · vol. 95(7) , pp. 2373–2378 · doi:10.1016/j.fertnstert.2011.03.030 · PMID:21474127 · W2023676014
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This study investigated follicle-stimulating hormone receptor signaling pathways in patients with endometriosis and those with poor ovarian reserve, identifying abnormalities in both groups.

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Abstract

ObjectiveTo study the integrity of the FSH receptor (FSHR) signaling pathway in granulosa-lutein cells at the time of egg retrieval and its relationship with the infertility diagnosis.DesignIn vitro assays.SettingUniversity laboratory and private IVF center.Patient(s)Patients undergoing IVF: 35 controls (no ovarian factor, NOF), 28 poor responders (PR), 32 patients with endometriosis (EM), and 22 patients with polycystic ovary syndrome (PCOS).Intervention(s)Quantitative reverse transcriptase-polymerase chain reaction (PCR) in granulosa-lutein cells from pooled follicles.Main outcome measure(s)Correlation between expression of FSHR and FSH-regulated genes PAPP/Cyp19A1.Result(s)Positive correlations among FSHR, PAPP, and Cyp19A1 expression levels are observed in NOF and are lost, with different patterns, in poor responder patients and those with endometriosis. Patients with endometriosis are an heterogeneous group including patients with poor ovarian reserve who behave like other poor responders patients (endometriosis-A) and patients with good response to ovarian stimulation (endometriosis-B) who show a specific alteration of the FSHR signaling pathway.Conclusion(s)These preliminary data suggest that the different signaling pathways activated through the FSHR in normal ovaries (NOF) are disrupted in poor responders and in patients with endometriosis. A better knowledge of the molecular origin of these errors may guide clinicians in the choice of personalized ovulation induction protocols for each type of ovarian dysfunction.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Luteal Cells Ovulation Receptors, FSH Signal Transduction Adult Analysis of Variance Aromatase Aromatase Case-Control Studies Endometriosis Endometriosis Endometriosis Female Fertility Agents, Female Fertility Agents, Female Fertilization in Vitro Humans Infertility, Female

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