EKSPRESI INTERLEUKIN-1 (IL-1) Β PADA ENDOMETRIOSIS, KARSINOMA ENDOMETRIOID DAN KARSINOMA SEROSUM OVARIUM

Nadia Nur Lestari, Siti Amarwati, Udadi Sadhana, Dik Puspasari
In: Biomedika · 2017 · vol. 8(1) · doi:10.23917/biomedika.v8i1.3016 · W2610266201
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This study compared interleukin-1 beta expression in ovarian endometriosis, endometrioid carcinoma, and serous carcinoma tissues, finding significant differences between endometriosis and the carcinomas, but not between the two carcinoma types.

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This cross-sectional study compared interleukin-1β (IL-1β) expression among re-evaluated formalin-fixed paraffin-embedded tissue samples from 30 cases across three groups: endometriosis, ovarian endometrioid carcinoma, and ovarian serous carcinoma. IL-1β was assessed using immunohistochemistry, and differences among groups were tested with one-way ANOVA and post hoc comparisons. IL-1β expression differed significantly among the three groups (p=0.037), with significantly higher expression in endometriosis versus both ovarian endometrioid and serous carcinoma groups, while endometrioid and serous carcinomas did not differ significantly (p=0.805). The study’s main limitation stated in the methods is its small, retrospective cross-sectional sample of 33 blocks/cases. This paper is centrally about endometriosis — it directly measures IL-1β expression in endometriosis tissue and compares it to ovarian cancer subtypes.

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Abstract

Endometriosis ovarium memiliki resiko keganasan epithelial ovarium (resiko relatif 1.9 sampai 4.2). Karsinoma endometrioid adalah salah satu jenis keganasan yang paling sering berhubungan dengan endometriosis, sementara karsinoma serosum merupakan keganasan epitelial terbanyak pada ovarium.Serum sitokin pro-inflamasi interleukin-1 (IL-1) β telah ditemukan berperan pada endometriosis dan karsinogenesis.Penelitian Keita, 2010, menemukan bahwa karsinoma endometrioid memiliki kadar IL-1β yang lebih tinggi secara bermakna dibandingkan jenis lainnya. Penelitian ini bertujua untuk mengetahui perbedaan ekspresi IL-1β pada jaringan endometriosis, karsinoma endometrioid dan karsinoma serosum ovarium. Desain penelitian ini adalah cross sectional design. Sampel adalah tiga puluh 33 blok parafin yang telah didiagnosis dan dire-evaluasi sebagai endometriosis (kelompok A), karsinoma endometrioid (kelompok B) dan karsinoma serosum ovarium (kelompok C) dan dilakukan pemeriksaan imunohistokimia IL-1β. Data ekspresi IL-1β dianalisis uji One Way ANOVA, dilanjutkan dengan uji beda rerata Post Hoc. Hasil uji One Way ANOVA kelompok A, B dan C, p = 0,037, menunjukkan adanya perbedaan bermakna. Uji beda rerata Post Hoc didapatkan kelompok A vs kelompok B dan C (p = 0,034 dan p = 0,020) bermakna. Sedangkan kelompok B vs kelompok C (p =0,805) tidak bermakna. Dari penelitian ini dapat disimpulkan terdapatperbedaan yang bermakna ekspresi IL-1β antara endometriosis dengan karsinoma endometrioid dan karsinoma serosum ovarium, namun tidak terdapat perbedaan yang bermakna ekspresi IL-1β antara karsinoma endometrioid ovarium dan karsinoma serosum ovarium.Kata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum
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Abstract

Penelitian Keita, 2010, menemukan bahwa karsinoma endometrioid memiliki kadar IL-1β yang lebih tinggi secara bermakna dibandingkan jenis lainnya. Penelitian ini bertujua untuk mengetahui perbedaan ekspresi IL-1β pada jaringan endometriosis, karsinoma endometrioid dan karsinoma serosum ovarium. Desain penelitian ini adalah cross sectional design. Sampel adalah tiga puluh 33 blok parafin yang telah didiagnosis dan dire-evaluasi sebagai endometriosis (kelompok A), karsinoma endometrioid (kelompok B) dan karsinoma serosum ovarium (kelompok C) dan dilakukan pemeriksaan imunohistokimia IL-1β. Data ekspresi IL-1β dianalisis uji One Way ANOVA, dilanjutkan dengan uji beda rerata Post Hoc. Hasil uji One Way ANOVA kelompok A, B dan C, p = 0,037, menunjukkan adanya perbedaan bermakna. Uji beda rerata Post Hoc didapatkan kelompok A vs kelompok B dan C (p = 0,034 dan p = 0,020) bermakna. Sedangkan kelompok B vs kelompok C (p =0,805) tidak bermakna. Dari penelitian ini dapat disimpulkan terdapatperbedaan yang bermakna ekspresi IL-1β antara endometriosis dengan karsinoma endometrioid dan karsinoma serosum ovarium, namun tidak terdapat perbedaan yang bermakna ekspresi IL-1β antara karsinoma endometrioid ovarium dan karsinoma serosum ovarium. Kata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum Full Text: PDFReferences Agarwal N, Subramanian A. 2010. Endometriosis - morphology, clincal presentations and molecular pathology. J Lab Physicians; 2(1):1-9. Dinarello CA, 1988. Biology of interleukin-1. FASEB J; 2:108-15 Furuya MS, 2012.Ovarian cancer stroma: Pathophysiology and the roles in cancer development. Cancers; 4:701-24 Gerard N, Caillaud M, Martoriati A, Goudet G, Lalmanach AC. 2004. The interleukin-1 system and female reproduction. JEndocrinol; 180:203-12. Hadisaputra W, Prayudhana S. 2013. Serum biomarker profiles of interleukin-6, tumor necrosis factor-alpha, matrixmetalloproteinase-2, and vascular endothelial growth factor in endometriosis staging. Med J indones; 22(2):76-82 Keita M, Bessette P, Pelmus M, Ainmelk Y, Aris A. 2010. Expression of interleukin-1 (IL-1) ligand system in the most common endometriosis associated ovarian cancer subtypes. J ovarian res; 3(3):1-8. Koshiyama M, Matsumura N, Konishi I. 2014. Recent concept of ovarian carcinogenesis: type I and type II. BioMed Res Int;1-11 Lawson C, Al-akoum M, Maheux R, Akoum A. 2007. Increased expression of interleukin-1 receptor type 1 in active endometriotic lesion.Reproduction; 133:265-74 Lebovic DI, Bentzien F, Chao VA, Garrett En, Meng YG, Taylor RN. 2000. Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1beta. Mol Hum Reprod; 6(3):269-75 Lin F, Pitchard J. 2015.Unknown primary/undifferentiated neoplasm.In Handbook of practical immunohistochemistry. New York: Springer; 131. Macciò A, Madeddu C., 2012. Inflammation and Ovarian Cancer, Ovarian Cancer – Basic Science Perspective, Dr. Samir Farghaly (Ed.), InTech, Available from:http://www.intechopen.com/books/ovarian-cancerbasic-science-perspective/inflammationand-ovarian-cancer, Italy. 2012.17-50 Munksgaard PS & Blaakaer J. 2011. The association between endometriosis and ovarian cancer: A review of histologycal, genetic and molecular alterations. Gynecol Oncol;1-6. doi:10.1016/j.ygyno.2011.10.001 Nezhat F, Datta S, Hanson V, Pejovic T, Nezhat C. 2008. The relationship between endometriosis and ovarian malignancy: a review. Fertil Steril; 90:1559-70. Robboy SJ, Haney A & Russell P. 2009. Endometriosis. In SJ Robboy, GL Mutter, J Prat, RC Bentley, P Russell, MC Anderson editors. Pathology of the Female Reproductive Tract. London: Churchill livingstone elsevier;.pp.515-41 Sourial S, Tempest N, Hapangama DK. 2014.Theories of the pathogenesis of endometriosis.Int J Reprod Med :1-10. Cited: 15 Oktober 2014 Terada T, 2012. Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis. Int J clin Exp pathol; 5(9):924-7. White KL, Schildkraut JM, Palmieri RT, 2012. Ovarian cancer risk associated with inherited inflammation-related variants. AmAssocCancerResJ:1-20. Cited: 27 Agustus 2014 Worley MJ, Welch WR, Berkowitz RS, Ng SW.,2013.Endometriosis-associated ovarian cancer: A review of pathogenesis. Int. J. Mol.Sci; 5367-79. Article Metrics

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