{"paper_id":"320ed83f-a20b-4283-8237-bf736570cee0","body_text":"EKSPRESI INTERLEUKIN-1 (IL-1) Β PADA ENDOMETRIOSIS, KARSINOMA ENDOMETRIOID DAN KARSINOMA SEROSUM OVARIUM\nNadia Nur Lestari(1*), Siti Amarwati(2), Udadi Sadhana(3), Dik Puspasari(4)(1)\n(2)\n(3)\n(4)\n(*) Corresponding Author\nAbstract\nPenelitian Keita, 2010, menemukan bahwa karsinoma endometrioid memiliki kadar IL-1β yang lebih tinggi secara bermakna dibandingkan jenis lainnya. Penelitian ini bertujua untuk mengetahui perbedaan ekspresi IL-1β pada jaringan endometriosis, karsinoma endometrioid dan karsinoma serosum ovarium. Desain penelitian ini adalah cross sectional design. Sampel adalah tiga puluh 33 blok parafin yang telah didiagnosis dan dire-evaluasi sebagai endometriosis (kelompok A), karsinoma endometrioid (kelompok B) dan karsinoma serosum ovarium (kelompok C) dan dilakukan pemeriksaan imunohistokimia IL-1β. Data ekspresi IL-1β dianalisis uji One Way ANOVA, dilanjutkan dengan uji beda rerata Post Hoc. Hasil uji One Way ANOVA kelompok A, B dan C, p = 0,037, menunjukkan adanya perbedaan bermakna. Uji beda rerata Post Hoc didapatkan kelompok A vs kelompok B dan C (p = 0,034 dan p = 0,020) bermakna. Sedangkan kelompok B vs kelompok C (p =0,805) tidak bermakna. Dari penelitian ini dapat disimpulkan terdapatperbedaan yang bermakna ekspresi IL-1β antara endometriosis dengan karsinoma endometrioid dan karsinoma serosum ovarium, namun tidak terdapat perbedaan yang bermakna ekspresi IL-1β antara karsinoma endometrioid ovarium dan karsinoma serosum ovarium.\nKata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum\nFull Text:\nPDFReferences\nAgarwal N, Subramanian A. 2010. Endometriosis - morphology, clincal presentations and\nmolecular pathology. J Lab Physicians; 2(1):1-9.\nDinarello CA, 1988. Biology of interleukin-1. FASEB J; 2:108-15\nFuruya MS, 2012.Ovarian cancer stroma: Pathophysiology and the roles in cancer development. Cancers; 4:701-24\nGerard N, Caillaud M, Martoriati A, Goudet G, Lalmanach AC. 2004. The interleukin-1 system and female reproduction. JEndocrinol; 180:203-12.\nHadisaputra W, Prayudhana S. 2013. Serum biomarker profiles of interleukin-6, tumor necrosis factor-alpha, matrixmetalloproteinase-2, and vascular endothelial growth factor in endometriosis staging. Med J indones; 22(2):76-82\nKeita M, Bessette P, Pelmus M, Ainmelk Y, Aris A. 2010. Expression of interleukin-1 (IL-1) ligand system in the most common endometriosis associated ovarian cancer subtypes. J ovarian res; 3(3):1-8.\nKoshiyama M, Matsumura N, Konishi I. 2014. Recent concept of ovarian carcinogenesis: type I and type II. BioMed Res Int;1-11\nLawson C, Al-akoum M, Maheux R, Akoum A. 2007. Increased expression of interleukin-1 receptor type 1 in active endometriotic lesion.Reproduction; 133:265-74\nLebovic DI, Bentzien F, Chao VA, Garrett En, Meng YG, Taylor RN. 2000. Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1beta. Mol Hum Reprod; 6(3):269-75\nLin F, Pitchard J. 2015.Unknown primary/undifferentiated neoplasm.In Handbook of practical immunohistochemistry. New York: Springer; 131.\nMacciò A, Madeddu C., 2012. Inflammation and Ovarian Cancer, Ovarian Cancer – Basic Science Perspective, Dr. Samir Farghaly (Ed.), InTech, Available from:http://www.intechopen.com/books/ovarian-cancerbasic-science-perspective/inflammationand-ovarian-cancer, Italy. 2012.17-50\nMunksgaard PS & Blaakaer J. 2011. The association between endometriosis and ovarian cancer: A review of histologycal, genetic and molecular alterations. Gynecol Oncol;1-6. doi:10.1016/j.ygyno.2011.10.001\nNezhat F, Datta S, Hanson V, Pejovic T, Nezhat C. 2008. The relationship between endometriosis and ovarian malignancy: a review. Fertil Steril; 90:1559-70.\nRobboy SJ, Haney A & Russell P. 2009. Endometriosis. In SJ Robboy, GL Mutter, J Prat, RC Bentley, P Russell, MC Anderson editors. Pathology of the Female Reproductive Tract. London: Churchill livingstone elsevier;.pp.515-41\nSourial S, Tempest N, Hapangama DK. 2014.Theories of the pathogenesis of endometriosis.Int J Reprod Med :1-10. Cited: 15 Oktober 2014\nTerada T, 2012. Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis. Int J clin Exp pathol; 5(9):924-7.\nWhite KL, Schildkraut JM, Palmieri RT, 2012. Ovarian cancer risk associated with inherited inflammation-related variants. AmAssocCancerResJ:1-20. Cited: 27 Agustus 2014\nWorley MJ, Welch WR, Berkowitz RS, Ng SW.,2013.Endometriosis-associated ovarian cancer: A review of pathogenesis. Int. J. Mol.Sci; 5367-79.\nArticle Metrics\nAbstract view(s): 1150 time(s)PDF: 1236 time(s)\nRefbacks\n- There are currently no refbacks.","source_license":"CC0","license_restricted":false}