Synchronous endometrioid tumors of the ovary and endometrium. A clinicopathologic study of 22 cases

S S Falkenberry, Falkenberry Ss, Steinhoff MM, M M Steinhoff, Gordinier M, Mary E. Gordinier, M Gordinier, Rappoport S, S Rappoport, W Gajewski, Gajewski W, Granai CO, C O Granai
The Journal of reproductive medicine · 1996 · vol. 41(10) , pp. 713–8 · PMID:8913971 · W2463808980
Other OA: closed CC0 ⤵ 13 in-corpus citations
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This study analyzed 22 patients with synchronous endometrioid tumors of the ovary and endometrium, finding they were generally younger, low-grade, early-stage, often associated with endometriosis, and survival correlated with individual tumor stage.

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Abstract

OBJECTIVE: To analyze a group of 22 patients with synchronous endometrioid tumors of the ovary and endometrium. STUDY DESIGN: A retrospective chart review was undertaken and information collected on patient age, parity, tumor grade and stage, presence of coexisting endometriosis and survival. Flow cytometry was determined from archival samples of the endometrial and ovarian tumors. RESULTS: The mean age at diagnosis was 52.8 years (range 36-71); mean parity was 1.05. With regard to the endometrial component, 68.2% were grade 1, 63.6% were stage I and, by flow cytometry, 62.5% were aneuploid. With regard to the ovarian lesions, 68.2% were grade 1, 68.2% were stage I, and 71.4% were aneuploid by flow cytometry. Twelve (54.5%) of 22 patients had pathologic evidence of coexisting endometriosis. Overall, three-year survival was 75%. All 11 patients with stage I disease at both sites were alive, without disease, at a mean follow-up of 34.9 months. CONCLUSION: Patients with synchronous endometrioid tumors of the endometrium and ovary are generally younger than reported for either endometrial adenocarcinomas or ovarian epithelial adenocarcinomas. They tend to be low grade and early stage and are frequently associated with endometriosis. Our data suggest that the survival of patients with synchronous primaries correlates with the stage of the individual tumors and that a second, synchronous primary does not adversely affect prognosis.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Adenoma Endometrial Neoplasms Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenoma Adenoma Adenoma Adenoma Adult Adult Aged Aged DNA, Neoplasm DNA, Neoplasm DNA, Neoplasm Endometrial Neoplasms

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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License: CC0 · commercial use OK