Synchronous primary tumors of the endometrium and ovary

Shovana Karki, U Chapagain
In: Journal of Pathology of Nepal · 1970 · vol. 2(3) , pp. 189–192 · doi:10.3126/jpn.v2i3.6019 · W2014247593
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This retrospective study characterized 10 cases of synchronous endometrial and ovarian cancers, finding that younger, premenopausal women were predisposed to developing dual primary tumors.

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This retrospective pathology study (Sept 2006–Aug 2011) characterized 10 patients with simultaneously detected endometrial and ovarian cancers, using data retrieved from a hospital database and applying published pathological criteria to distinguish synchronous primary tumors from metastatic disease. Seven cases were classified as synchronous primary endometrial and ovarian cancers, and three as metastatic tumors; the median age was 47.4 years, and most synchronous cases involved premenopausal women, with low-grade histology reported in a substantial fraction. The authors found atypical endometrial hyperplasia in 42.8% of cases, and they stated that none of the cases showed endometriosis. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match and notes absence of endometriosis among findings, though it is primarily about synchronous endometrial and ovarian tumors.

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Abstract

Background: Primary synchronous cancer of the female genital tract is a relatively uncommon. Simultaneously detected endometrial and ovarian malignancies constitute the commonest occurrence. A set of pathological criteria has been described to differentiate synchronous primaries from metastatic tumors. The purpose of this study was to characterize patients with synchronous primary endometrial and ovarian tumors. Materials and Methods: This was a retrospective study done in Department of Pathology, Tribhuwan University Teaching Hospital from September 2006 to August 2011. The datas were retrieved from computer database. Results: There were totally of 10 cases of simultaneously detected endometrial and ovarian cancers. Out of 10 cases, 7 cases were synchronous primary endometrial and ovarian cancers while three were metastatic. Median age at presentation was 47.4 years. Six (85.8%) of these patients presenting with dual primary tumors were premenopausal. Grade 1 histology was seen in 57% of endometrial and 42% of ovarian tumors. Atypical endometrial hyperplasia was found in 42.8% of cases while none of the cases showed endometriosis. Conclusion: Though limited by relatively small number of cases, younger and premenopausal women were predisposed to developing synchronous primary tumors of the endometrium and ovary. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6019 JPN 2012; 2(3): 189-192
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Background

Primary synchronous cancer of the female genital tract is a relatively uncommon. Simultaneously detected endometrial and ovarian malignancies constitute the commonest occurrence. A set of pathological criteria has been described to differentiate synchronous primaries from metastatic tumors. The purpose of this study was to characterize patients with synchronous primary endometrial and ovarian tumors.

Materials and methods

This was a retrospective study done in Department of Pathology, Tribhuwan University Teaching Hospital from September 2006 to August 2011. The datas were retrieved from computer database.

Results

There were totally of 10 cases of simultaneously detected endometrial and ovarian cancers. Out of 10 cases, 7 cases were synchronous primary endometrial and ovarian cancers while three were metastatic. Median age at presentation was 47.4 years. Six (85.8%) of these patients presenting with dual primary tumors were premenopausal. Grade 1 histology was seen in 57% of endometrial and 42% of ovarian tumors. Atypical endometrial hyperplasia was found in 42.8% of cases while none of the cases showed endometriosis.

Conclusion

Though limited by relatively small number of cases, younger and premenopausal women were predisposed to developing synchronous primary tumors of the endometrium and ovary. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6019 JPN 2012; 2(3): 189-192 Downloads Downloads How to Cite Issue Section License This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

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endometriosis

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