Impact of estrogen and progesterone receptor expression on the incidence of endometrial polyps

Cuiyun Yan, Chunping Xing, Tao Wei, Hui Zhou, Hua Wang, Tao Liu, Jiefang Gao
Biomarkers in medicine · 2023 · vol. 17(21) , pp. 881–887 · doi:10.2217/bmm-2023-0411 · PMID:38230984 · W4390943877
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Estrogen receptor expression was higher and progesterone receptor lower in endometrial polyp patients compared to controls, correlating with polyp incidence.

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Abstract

Aim: We studied the association of estrogen receptor (ER) and progesterone receptor (PR) with endometrial polyp (EP) formation. Methods: A total of 129 EP patients and an equal number of disease-free women were evaluated for ER and PR expression in endometrial tissues. Correlation with EP incidence was analyzed, as well as diagnostic value via receiver operating characteristic curve. Results: ER expression was higher and PR was lower in patients than in controls (p < 0.01). ER levels positively correlated with EP incidence, and PR negatively (p < 0.01). Receiver operating characteristic curves gave ER an area under the curve of 0.6168 (95% CI: 0.5479-0.6856; p < 0.0001) and PR 0.739 (95% CI: 0.6776-0.8003; p < 0.0001). Conclusion: Imbalance in ER and PR expression associates with EPs formation, offering clinical insights into EP pathology.

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MeSH descriptors

Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Polyps Polyps Polyps Polyps Endometrium Endometrium Endometrium Estrogens Estrogens Female Humans Incidence Progesterone Progesterone Receptors, Estrogen Receptors, Estrogen

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